Conditioning of the body as healthy medicine

Volume 9, Issue 4, August 2024     |     PP. 130-142      |     PDF (382 K)    |     Pub. Date: September 10, 2024
DOI: 10.54647/cm321291    36 Downloads     1805 Views  

Author(s)

David Wing-Ching Lee, Department of Cardiology, Jen Ai Hospital, Tali, Taichung, Taiwan.
William Wing-Ho Lee, Department of Cardiology, Jen Ai Hospital, Tali, Taichung, Taiwan.
Andrew Ying-Siu Lee, Department of Cardiology, Jen Ai Hospital, Tali, Taichung, Taiwan.

Abstract
At this time, heart conditioning, which is hormetic stress on the cardiovascular system, is utilized as a healthy strategy, compatible to the heterochronic parabiotic model, in the reversion of disease and aging! The other body systems such as lung and gut conditioning can be utilized as healthy strategies as well. Thus, conditioning of the whole body is a possible healthy medicine, which can oppose, tolerate, treat and reverse disease and aging.

Keywords
heart conditioning; heterochronic parabiosis; healthy medicine hormetic stress; healthy medicine

Cite this paper
David Wing-Ching Lee, William Wing-Ho Lee, Andrew Ying-Siu Lee, Conditioning of the body as healthy medicine , SCIREA Journal of Clinical Medicine. Volume 9, Issue 4, August 2024 | PP. 130-142. 10.54647/cm321291

References

[ 1 ] Bernard C. Les Phenomenes de la Vic. Paris 1878, two vols.
[ 2 ] Finerty, J.C., Binhammer, R., Schnerder, M.,. Protection of irradiated rats by parabiosis. Tex. Rep. Biol. Med. 1952;10:496-500
[ 3 ] Hall, C.E., Hall, O., Neris, A.H.,. Prolongation of survival by parabiosis in strain 129 dystrophic mice. Am. J. Physiol.1959;196:110-2
[ 4 ] Pope, F., Lunsford, W., McCay, C.M.,. Experimental prolongation of the life span. J. Chronic Dis. 1956;4:153-8
[ 5 ] Conboy, I.M., Conboy, M.J., Wagers, A.J.,Girma ER, Weissman IL, Rando TA. Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature2005;433:760-4
[ 6 ] Ruckh, J.M.,Zhao JW, Shadrach JL, Wijngaarden PV, Rao TN, Wagers AJ, Franklin RJM.. Rejuvenation of regeneration in the aging central nervous system. Cell Stem cell 2012;10:96-103
[ 7 ] Loffredo, F.S., Steinhauser, M.L., Jay, S.M., Gannon J, Pancoast JR, Yalamanchi P, Sinha M, Dall’Osso C, Serwold T, Wagers AJ, Lee RT.. Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy. Cell2013;153:828-39
[ 8 ] Huang, Q., Ning, Y., Liu, D., Zhay Y, Li D, Zhang Y, Yiu Z, Du B, Cai G, Sun X, Chen X.. A young blood environment decreases aging of senile mice kidneys. J. Gerontol. A Biol. Sci. Med. Sci.2018;73(4):421-8
[ 9 ] Lee AYS. Heart conditioning and heterochronic parabiotic models as healthy strategies. SN Comprehensive Clinical Medicine2023; 5:6.
[ 10 ] Murry, C.E., Jennings, R.B., Reimer, K.A., Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Cir. 1986.;74:1124-36.
[ 11 ] Sumeray, M.S., Yellon, D.M.,. Characterization and validation of a murine model of global ischemia-reperfusion injury. Mol. Cell.Biochem.1998;186:61-8.
[ 12 ] Leslay, W.K., Beach, D.,. Frequency and clinical significance of ischemic preconditioning during percutaneous coronary intervention. J. Am. Coll. Cardiol. 2003;42:998-1003.
[ 13 ] Walsh, S.R., Tang, T.Y., Kullar, P. , Jenkins DP, Dutka DP, Gaunt ME. Ischemic preconditioning during cardiac surgery: systemic review and meta-analysis of perioperative outcomes in randomized clinical trials. Eur. J. Cardio. Thorac. Surg. 2008;34:985-94.
[ 14 ] Heusch, G., Botker, H.E., Przyklenk, K., Redington A, Yellon D.Remote ischemic conditioning. J. Am. Coll. Cardiol.2015;65:177-95.
[ 15 ] Przyklenk, K., Whittaker, P. Remote ischemic preconditioning: current knowledge, unresolved questions, and future priorities. J. Cardiovas. Pharmacol. Ther. 2011;16(3-4): 255-9.
[ 16 ] Elwood W, Barnes PJ, Chung KF. Airway hyperresponsiveness is associated with inflammatory cell infiltration in allergic brown Norway rats. Int Arch Allergy Immunol1992;99(1):91-7.
[ 17 ] Weiler-Ravell D, Godfrey S. Do exercise- and antigen-induced asthma utilize the same pathways? Antigen provocation in patients rendered refractory to exercise-induced asthma. J Allergy Clin Immunol1981;67:391-7.
[ 18 ] Craig TJ and Dispenza MC. Benefits of exercise in asthma. Ann Allergy Asthma Immunol 2013;110:133-40.
[ 19 ] Turan NN, Demiryurek AT. Preconditioning effects of peroxynitrite in the rat lung. Pharmacol Res2006;54:380-8.
[ 20 ] Jan WC, Chen CH, Tsai PS, Huang CJ. Limb ischemic preconditioning mitigates lung injury induced by hemorrhagic shock/resuscitation in rats. Resuscitation2011;82:760-6.
[ 21 ] Xia ZY, Gao J, Ancharaz AK et al. Ischemic postconditioning protects lung from ischemia-reperfusion injury by up-regulation of heme-oxygenase. Int J Care Injured 2010;41:510-6.
[ 22 ] Kim CH, Sajgalik P, Iterson EHV, Jae SY, Johnson BD. The effect of remote ischemic preconditioning on pulmonary vascular pressure and gas exchange in healthy humans during hypoxia. RespPhysiol Neurobiology2019;161:62-6.
[ 23 ] Zhou W, Zeng D, Chen R, Liu J, Yang G, Liu P, Zhou X. Limb ischemic preconditioning reduces heart and lung injury after an open heart operation in infants. PediatrCardiol2010;31:22-29.
[ 24 ] Most J, Tosti V, Redman LM, Fontana L. Calorie restriction in humans: an update. Aging Res Reviews2017;39:36-45.
[ 25 ] Shariatpanshi ZV, Shariatpanahi MV, Shahbazi S, Hossaini A, Abadi A. Effect of Ramadan fasting on some indices of insulin resistance and components of the metabolic syndrome in healthy male adults. Br J Nutr2008;100(1):147-51.
[ 26 ] Mattson MP, Wan R. Beneficial effects of intermittent fasting and calorie restriction on the cardiovascular and cerebrovascular systems. J NutrBiochem2005;16(3):129-37.
[ 27 ] Bagherniya M, Butler AE,Barreto GE, Sahebkar A. The effect of fasting or calorie restriction on autophagy induction: A review. Ageing Res Reviews2018;47:183-97.
[ 28 ] Pajdo R, Closa D, Xaus C, Kwiecien S, Konturek S, Sliwowski A, Pawlik M, Ptak A, Drozdowicz D, Hahn EG. Ischemic preconditioning, the most effective gastroprotective intervention: involvement of prostaglandins, nitric oxide, adenosine and sensory nerves. Eur J Pharmacol2001;427:263-76.
[ 29 ] Zitta K, Meybohm P, Bein B, Heinrich A, Renner J, Cremer J, Steinfath M, Scholz J, Albrecht M. Serum from patients undergoing remote ischemic preconditioning protects cultured human intestinal cells from hypoxia induced damage: involvement of matrix metalloproteinase 2 and 9. Mol Med 2012;18:29-37.
[ 30 ] Li C, Li YS, Xu M, Wen SH, Yao Y, Wu Y, Huang CY, Huang WQ, Liu KX.Limb remote ischemic preconditioning for intestinal and pulmonary protection during elective open infrarenal abdominal aortic aneurysm repair randomized controlled trial. J Am SocAnesthesiol2013;118:842-52.