Micropeptides Related to Tumors: Candidates for Tumor Targeted Therapies and Diagnostic Biomarkers

Volume 9, Issue 3, June 2024     |     PP. 67-78      |     PDF (284 K)    |     Pub. Date: October 30, 2024
DOI: 10.54647/biology180377    21 Downloads     652 Views  

Author(s)

Zhang Taoyangshu, Institute of Basic Medicine and Forensic Medicine, North Sichuan Medical College, Nanchong 637000, China
Li Dajiang, School of Pharmacy, North Sichuan Medical College, Nanchong 637000, China
Kang Aijia, School of Clinical Medicine, North Sichuan Medical College, Nanchong 637000, China
Tan Xiao, School of Clinical Medicine, North Sichuan Medical College, Nanchong 637000, China
Liu Hongmei, School of Clinical Medicine, North Sichuan Medical College, Nanchong 637000, China
Zhang Shuting, School of Clinical Medicine, North Sichuan Medical College, Nanchong 637000, China
Yin Xinqiang, School of Pharmacy, North Sichuan Medical College, Nanchong 637000, China

Abstract
A number of RNAs, which have been annotated as non-coding RNA, encode proteins less than 100 amino acids. The ORFs less than 100 codes are called small open reading frames（sORFs）. sORFs encode proteins called micropeptides. Though many micropeptides have been identified in several species, there are gaps in mining micropeptides from thousands of ncRNAs. But developing technologies help us to find more and more sORFs and micropeptides. To date, micropeptides are found to involve in various cancers, and can be used as prognostic biomarkers and therapeutic targets. This review discusses the micropeptides which have been discovered in cancers. However, there are gaps that remain unclear. The resulting picture is micropeptides need to be deep-going. And in the future, the research of micropeptides related to cancers also will be a hot topic.

Keywords
sORFs, micropeptides, cancer, diagnostic biomarker, Targeted Therapies, ncRNAs

Cite this paper
Zhang Taoyangshu, Li Dajiang, Kang Aijia, Tan Xiao, Liu Hongmei, Zhang Shuting, Yin Xinqiang, Micropeptides Related to Tumors: Candidates for Tumor Targeted Therapies and Diagnostic Biomarkers , SCIREA Journal of Biology. Volume 9, Issue 3, June 2024 | PP. 67-78. 10.54647/biology180377

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