Delayed systemic reactions to infliximab retreatment in Crohn’s disease

Volume 4, Issue 5, October 2019     |     PP. 186-190      |     PDF (147 K)    |     Pub. Date: October 6, 2019
DOI:    226 Downloads     5866 Views  

Author(s)

Shi Hui, Department of Gastroenterology and hepatology, Jinling Hospital, China.
Ye Lei, Department of Gastroenterology and hepatology, Jinling Hospital, China.
Lu Hen, Department of Gastroenterology and hepatology, Jinling Hospital, China.
Yang Miaofang, Department of Gastroenterology and hepatology, Jinling Hospital, China.
Liu Chang, Department of Gastroenterology and hepatology, Jinling Hospital, China.
Wang Fangyu, Department of Gastroenterology and hepatology, Jinling Hospital, China.

Abstract
Objective To improve the understanding of Delayed systemic reactions to infliximab retreatment.Method Two cases of anaphylactic reaction following infliximab infusion in patients with active Crohn’s disease(CD) were reported. Both had previously received infliximab treatment over more than one year ago. Related literatures were reviewed.Result Two young male CD patients who obtained remission after infliximab treatment several years ago got flared and received infliximab infusion again. One got arthralgias and the other got myalgias. Both relieved after discontinuation. Conclusion A distant infliximab retreatment is associated with high rates of anaphylactic reaction. Careful monitoring should be adopted in those patients who receive infliximab retreatment.

Keywords
myalgias, arthralgias, infliximab retreatment, Crohn’s disease

Cite this paper
Shi Hui, Ye Lei, Lu Hen, Yang Miaofang, Liu Chang, Wang Fangyu, Delayed systemic reactions to infliximab retreatment in Crohn’s disease , SCIREA Journal of Clinical Medicine. Volume 4, Issue 5, October 2019 | PP. 186-190.

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