Risk of juvenile fibromyalgia among Taiwan adolescents: Nationwide population-based study from 2000 to 2010

Volume 1, Issue 2, December 2016     |     PP. 183-195      |     PDF (361 K)    |     Pub. Date: December 21, 2016
DOI:    357 Downloads     6804 Views  

Author(s)

Hsin-Li Liu, Department of Nursing, Central Taiwan University of Science and Technology;
Chuan-Mei Chen, Department of Nursing, Central Taiwan University of Science and Technology.
Liang -Guei Huang, Department of Nursing, Central Taiwan University of Science and Technology
Horng -Mo Lee, School of Medical Laboratory Sciences and Biotechnology, Taipei Medical University.
Yueh-Chin Chung, Department of Nursing, Central Taiwan University of Science and Technology

Abstract
Background: The incidence of juvenile fibromyalgia (JFM) in Taiwan has yet to be documented. As such, we investigated the incidence, risk factors, and comorbidities of JFM in this country.Methods: We analyzed the 2000–2010 claims data of outpatients diagnosed with JFM (ICD-9-CM codes 729.1) from the National Health Insurance Research Database.Results: A total of 9,808 females (52.38%) and 8,916 males (47.62%) were included in this study. The male-to-female ratio was 0.99–0.95 among 16- to 18-year-old individuals. The JFM with the highest incidence was observed in the 15- to 18-year-old age group. The annual incidences of JFM peaked in 2004 (235.10 per 1,000 people/year). Comorbidities with all JFM included Signs, symptoms, and ill-defined conditions(65.29%) and Gastrointestinal conditions (17.86%). The incidence of JFM among the female patients with Signs, symptoms,and ill-defined conditions and Gastrointestinal conditions were significantly higher than that among the patients without JFM (OR = 1.09, 95% confidence interval (CI) = 1.03–1.16, p < 0.003; OR = 1.10, 95% confidence interval (CI) = 1.01–1.20, p <0.026). The incidence of JFM among the male patients with Signs, symptoms, and ill-defined conditions was significantly higher than that among the patients without JFM (OR =1.09, 95% confidence interval (CI) = 1.03 –1.16, p < 0.0062). Conclusions: Differences in comorbidities with JFM were observed. Additional multidisciplinary intervention strategies should be developed to detect and treat JFM.

Keywords
juvenile fibromyalgia, pediatric, incidence, nationwide population-based study

Cite this paper
Hsin-Li Liu, Chuan-Mei Chen, Liang -Guei Huang, Horng -Mo Lee, Yueh-Chin Chung, Risk of juvenile fibromyalgia among Taiwan adolescents: Nationwide population-based study from 2000 to 2010 , SCIREA Journal of Clinical Medicine. Volume 1, Issue 2, December 2016 | PP. 183-195.

References

[ 1 ] Buskila D. Pediatric fibromyalgia. Rheum Dis Clin North Am 2009; 35:253–61.
[ 2 ] Durmaz Y, Alayli G, Canbaz S, Zahiroglu Y, Bilgici A, Ilhanli I. Prevalence of juvenile fibromyalgia syndrome in an urban population of Turkish adolescents: impact on depressive symptoms, quality of life and school performance. Chin Med J (Engl) 2013; 126:3705–11.
[ 3 ] Sil S, Thomas S, DiCesare C, et al. Preliminary evidence of altered biomechanics in adolescents with juvenile fibromyalgia. Arthritis Care Res (Hoboken) 2015; 67:102-11.
[ 4 ] Durmaz Y, Alayli G, Canbaz S, et al. Prevalence of juvenile fibromyalgia syndrome in an urban population of Turkish adolescents: impact on depressive symptoms, quality of life and school performance.Chin Med J (Engl) 2013; 126:3705-11.
[ 5 ] Sil S, Lynch-Jordan A, Ting TV, Peugh J, Noll J, Kashikar-Zuck S.Influence of family environment on long-term psychosocial functioning of adolescents with juvenile fibromyalgia. Arthritis Care Res (Hoboken) 2013; 65:903-9.
[ 6 ] Long AC, Krishnamurthy V, Palermo TM. Sleep disturbances in school-age children with Chronic pain. J Pediatr Psychol 2007; 33:258–68.
[ 7 ] Palermo TM, Wilson AC, Lewandowski AS, et al. Behavioral and psychosocial factors associated with insomnia in adolescents with chronic pain. Pain 2011; 152:89–94.
[ 8 ] Zernikow B, Gerhold K, Bürk G,et al. Definition, diagnosis and therapy of chronic widespread pain and so-called fibromyalgia syndrome in children and adolescents. Systematic literature review and guideline. Schmerz 2012; 26:318-30.
[ 9 ] Huguet A, Miro J.The severity of chronic pediatric pain: an epidemiological study. J Pain 2008; 9:226–36.
[ 10 ] Palermo TM. Enhancing daily functioning with exposure and acceptance strategies: an important stride in the development of psychological therapies for pediatric chronic pain. Pain 2009 142:189–90.
[ 11 ] Varni JW, Burwinkle TM, Limbers CA, Szer IS. The PedsQL as a patient-reported outcome in children and adolescents with fibromyalgia: an analysis of OMERACT domains. Health Qual Life Outcomes 2007; 5:9.
[ 12 ] Kashikar-Zuck S, Ting TV. Juvenile fibromyalgia: current status of research and future developments. Nat Rev Rheumatol 2014; 102:89-96.
[ 13 ] Kashikar-Zuck S, Zafar M, Barnett KA, et al. Quality of life and emotional functioning in youth with chronic migraine and juvenile fibromyalgia.Clin J Pain 2013; 29:1066-72.
[ 14 ] Yokota S, Kikuchi M, Miyamae T.Juvenile fibromyalgia: Guidance for management. Pediatr Int 2013; 55:403-9.
[ 15 ] Buskila D, Ablin J. Pediatric fibromyalgia.Reumatismo 2012;64:230-7.
[ 16 ] McLeod JD. Juvenile fibromyalgia syndrome and improved recognition by pediatric primary care providers. J Pediatr Health Care 2014; 28:e9-18.
[ 17 ] Arnold LM, Bateman L, Palmer RH, Lin Y. Preliminary experience using milnacipran in patients with juvenile fibromyalgia: lessons from a clinical trial program.Pediatr Rheumatol Online J 2015; 13:27.
[ 18 ] Buskila D, Press J, Gedalia A, et al. Assessment of nonarticular tenderness and prevalence of Fibromyalgia in children. J Rheumatol 1993; 20:368.
[ 19 ] Kashikar-Zuck S, Parkins IS, Ting TV, et al.Controlled follow-up study of physical and psychosocial functioning of adolescents with juvenile primary fibromyalgia syndrome. Rheumatology (Oxford) 2010; 49:2204–9.
[ 20 ] Du Y,Knopf H,Zhuang W,Ellert U. Pain perceived in a national community sample of German children and adolescents. Eur J Pain 2011; 15:649-57.
[ 21 ] Huguet A, Miro J. The severity of chronic pediatric pain: an epidemiological study. J Pain 2008; 9:226–36.
[ 22 ] Roth-Isigkeit A, Thyen U, Raspe HH, Stöven H, Schmucker P. Reports of pain among German children and adolescents:an epidemiological study. Acta Pediatrica 2004; 93:258–63.
[ 23 ] Perquin CW, Hazelbrock-Kampschreu AA, Hunfeld JA,Bohnen AM, Van Suijlekom-Smit LW, Passchier J, Van der Wouden J C. Pain in children and adolescents: A common experience. Pain 2000, 87, 51-58.
[ 24 ] Gedalia A, Garcia CO, Molina JF, Bradford NJ, Espinoza LR. Fibromyalgia syndrome: Experience in a pediatric rheumatology clinic. Clinical and Experimental Rheumatology 2000; 18,415-19.
[ 25 ] Lommel K, Kapoor S, Bamford J, Melguizo MS, Martin C, Crofford L. Juvenile primary ibromyalgia syndrome in an inpatient adolescent psychiatric population. Int J Adolesc Med Health 2009; 21:571-9.
[ 26 ] Mikkelsson M, El-Metwally A, Kautiainen H, et al. Onset, prognosis and risk factors for widespreadpain in schoolchildren: a prospective 4-yearfollow-up study. Pain 2008; 138:681–87.
[ 27 ] Mikkelsson M, Kaprio J, Salminen JJ, Pulkkinen L, Rose RJ. Widespread pain among 11 year old Finnish twin pairs. Arthritis Rheum 2001; 44:481–5.
[ 28 ] Gedalia A, Garcia CO, Molina JF, Bradford NJ, Espinoza LR. Fibromyalgia syndrome: experience in a pediatric rheumatology clinic. Clin Exp Rheumatol 2000; 18:415–9.
[ 29 ] David S. Bell, Karen M. Bell, and Paul R. Cheney.Primary juvenile fibromyalgia syndrome and chronic fatigue syndrome in adolescents. Clin Infect Dis 1994 ;18:S21-3.