Research progress of glioma-related molecular markers

Volume 5, Issue 2, April 2020     |     PP. 30-49      |     PDF (232 K)    |     Pub. Date: May 10, 2020
DOI:    245 Downloads     4781 Views  

Author(s)

Lai Xiong, Department of Medical Oncology, Cancer Center, West China Hospital, West China Medical School, Sichuan University, Sichuan, P.R. China
Xiao Qi Xie, Department of Critical Care Medicine, West China Hospital, Sichuan University, Sichuan, P.R. China
Wei Ming Li, Precision medicine center, West China Hospital, Sichuan University, Sichuan, P.R. China
Xin Wu, Department of Medical Oncology, Cancer Center, West China Hospital, West China Medical School, Sichuan University, Sichuan, P.R. China
Yong Luo, Department of Medical Oncology, Cancer Center, West China Hospital, West China Medical School, Sichuan University, Sichuan, P.R. China
Ping Ai, Department of Medical Oncology, Cancer Center, West China Hospital, West China Medical School, Sichuan University, Sichuan, P.R. China
Feng Wang, Department of Medical Oncology, Cancer Center, West China Hospital, West China Medical School, Sichuan University, Sichuan, P.R. China
Deng Bing Wu, Cancer Hospital, Ansteel Group Hospital, Anshan, Liao Ning, P.R. China
Yuan Zhao Liu, Department of Radiotherapy, Beijing Hospital, Beijing, P.R. China
Jing Bo Kang, Department of Radiotherapy, The Sixth Medical Center of PLA General Hospital, Beijing, P.R. China
RuoYuWang, Department of Medical Oncology, Affiliated Zhongshan Hospital of Dalian University, Dalian China
Bao Lin Qu, Department of Radiotherapy, Chinese PLA General Hospital, Beijing, P.R. China
Xian Feng Li, Department of Radiotherapy, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, P.R. China
Jun Jie Wang, Department of Radiation Oncology Cancer Center Peking University 3rd Hospital P.R. China

Abstract
Glioma is a primary brain tumor with a high incidence and a poor prognosis. Although it is treated by surgery, radiotherapy and other methods, the prognosis of patients is still not satisfactory. With the continuous development of medical technology, more and more Many biological molecular markers are recognized.The combined deletion of 1p / 19q is considered to be a characteristic molecular marker and independent prognostic factor in oligodendro glioma, and it can also be used as an important indicator to evaluate the sensitivity of chemotherapy. MGMT promoter methylated glioma patients are often more sensitive to chemotherapy drugs. IDH1 mutations occur widely in different types of gliomas such as oligodendroglioma and diffuse astrocytoma and suggest a good prognosis. The most common type of EGFR mutation is EGFRv III, which can enhance tumorigenicity, proliferation, migration and invasiveness of tumor cells. Positive EGFRv III in tumor tissues indicates a poor prognosis. CAR-targeting EGFRv III T-cell adoptive immunotherapy for glioblastoma multiforme has become a research hotspot. VEGF can promote angiogenesis in gliomas, and its expression is related to the pathological grade of gliomas. TERT activationMutations can enhance telomerase activity and lead to unlimited proliferation of tumor cells. The mutation rate of BRAF is higher in low-grade gliomas such as hairy cell astrocytoma and children's gliomas. ATRX gene mutation, TP53 gene mutation, ppENK activation Methylation of the daughter is also of diagnostic significance for the precise pathological typing of gliomas. In addition, some miRNAs and lnc RNAs have become a hot topic in the field of glioma molecular markers. With more and more of these molecules With the study of markers, we are continuously moving towards the precise diagnosis of glioma, individualized treatment and improvement of prognosis.

Keywords
glioma, prognosis, molecular markers

Cite this paper
Lai Xiong, Xiao Qi Xie, Wei Ming Li, Xin Wu, Yong Luo, Ping Ai, Feng Wang, Deng Bing Wu, Yuan Zhao Liu, Jing Bo Kang, RuoYuWang, Bao Lin Qu, Xian Feng Li, Jun Jie Wang, Research progress of glioma-related molecular markers , SCIREA Journal of Clinical Medicine. Volume 5, Issue 2, April 2020 | PP. 30-49.

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