REACTIVE MORPHOLOGICAL CHANGES OF RATS’ HEARTS WITH AN EXPERIMENTAL UNDIFFERENTIATED DYSPLASIA OF CONNECTIVE TISSUE

Volume 5, Issue 5, October 2020     |     PP. 89-107      |     PDF (521 K)    |     Pub. Date: September 22, 2020
DOI:    200 Downloads     4816 Views  

Author(s)

Hryhorieva O. A., Normal Anatomy, Operative Surgery and Topographic Anatomy Department, Zaporizhzhya State Medical University, Zaporizhzhya, Ukraine
Guminskiy Yu.Yo., Normal Anatomy Department, National Pirogov Memorial Medical University, Vinnitsa, Ukraine
Chernyavskiy A. V., Normal Anatomy, Operative Surgery and Topographic Anatomy Department, Zaporizhzhya State Medical University, Zaporizhzhya, Ukraine
Tavrog M.L., Normal Anatomy, Operative Surgery and Topographic Anatomy Department, Zaporizhzhya State Medical University, Zaporizhzhya, Ukraine
Zinich O.L., Normal Anatomy, Operative Surgery and Topographic Anatomy Department, Zaporizhzhya State Medical University, Zaporizhzhya, Ukraine

Abstract
In modern literature, there are sufficient data concerning clinical manifestations of connective tissue dysplasia, its diagnosis, principles of correction, but works devoted to factors that lead to dysplasia, and morphological manifestations of this condition are insufficient.The aim: to establish a reactive morphological changes of the heart of rats with an experimental undifferentiated dysplasia of connective tissue.Materials and methods. As an experimental model of undifferentiated dysplasia of connective tissue it is selected a model of intrafetal antigens injection at the 18 th day of dated pregnancy. The object of the study was 144 hearts of white laboratory rats, which were divided into 3 groups: - The 1st one – intact animals; the 2nd group consisted of experimental animals; the 3rd group consisted of control rats. Histochemical, histological methods, statistic methods were used in the work. It is settled that in rats with an experimental undifferentiated dysplasia of connective tissuethe thinning of the hearts’ walls from birth up to the 45th day of life is defined compared to control, it is most pronounced at the 1st and 9th day of life. In the group of experimental rats, starting from the 21st day of life up to the end of the observation period the relative area occupied by connective tissue fibers is lower compared to control. This happens mainly due to the lower proportion of collagen fibers type III from the 14th up to the 45th day of life. In experimental rats with undifferentiated dysplasia of connective tissue a significant thinning of the intima-media complex of the arteries of the heart was observed throughout the observation period with the most pronounced changes at the 3rd (3,35±0,09 µm vs 4,95±1.03 µm in controls) and the 21st (7,57±0,25 µm vs. 9.5±of 1.62 µm in controls) days of life, p<0.01.

Keywords
undifferentiated dysplasia of connective tissue, heart, collagen fibers, lymphocytes, intrafetal antigen injection

Cite this paper
Hryhorieva O. A., Guminskiy Yu.Yo., Chernyavskiy A. V., Tavrog M.L., Zinich O.L., REACTIVE MORPHOLOGICAL CHANGES OF RATS’ HEARTS WITH AN EXPERIMENTAL UNDIFFERENTIATED DYSPLASIA OF CONNECTIVE TISSUE , SCIREA Journal of Clinical Medicine. Volume 5, Issue 5, October 2020 | PP. 89-107.

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