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Paul H. Hartel, MD, Davis Medical Center of Davis Health System, Elkins, West Virgini;West Virginia School of Medicine, Morgantown, West Virginia;West Virginia School of Osteopathic Medicine, Lewisburg, West Virginia.
Donald R. Fleming, MD, Davis Medical Center of Davis Health System, Elkins, West Virgini;West Virginia School of Medicine, Morgantown, West Virginia;West Virginia School of Osteopathic Medicine, Lewisburg, West Virginia.
While targeted therapies are available for breast cancer patients whose tumors express ER, PR, or show HER-2 overexpression, no such treatment exists for “triple-negative” cases. As immunohistiochemistry (IHC) expression of Cyclin D1 has been shown concordant with Cyclin D1 gene amplification, we evaluated Cyclin D1 IHC expression in 25 cases of triple-negative invasive ductal carcinoma to clarify its relationship with clinical and pathologic parameters. Twenty-six invasive carcinomas negative for ER, PR, and HER-2 were reviewed. Clinical information, including treatment response, was gleaned from patient records. Tumors were morphologically reviewed and Cyclin D1 IHC applied using BCL-1. Chi square and t-test statistical analyses were performed. Patients were female and had a mean age of 59 years. Tumors were invasive ductal carcinomas of no special type, Nottingham grade 1, 2 and 3. All tumors showed Cyclin D1 expression from light and focal staining to focal intense staining. Patients with tumors showing intense BCL-1 staining had larger tumors with more capillary/lymphatic invasion and lymph node metastases and were less likely to respond to treatment. Cyclin D1 expression may serve as a marker for more biologically aggressive triple-negative breast cancer. These tumors may respond to targeted therapy that down-regulates Cyclin D1 amplification. Further research with larger sample sizes is needed.
triple negative, breast cancer, invasive ductal carcinoma, cyclin D1, immunohistochemistry, personalized medicine
Cite this paper
Paul H. Hartel, MD, Donald R. Fleming, MD, Cyclin D1 expression in triple-negative breast cancer with new treatment implications, SCIREA Journal of Clinical Medicine. Vol. 1 , No. 1 , 2016 , pp. 49 - 57 .
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