Simiao Yongan Decoction in Treating Herpes Zoster: A Network Pharmacology- Based study

Abstract
Background Herpes zoster (HZ) is an infectious disease, which impacts on patients' quality of life. Herein, we employed the network pharmacological methods to predict the target of bioactive components in Simiao Yongan Decoction (SYD) in the treatment of HZ.
Method We utilized the TCMSP and GenneCards databases to screen for the bioactive components of SYD, their targets, and HZ related targets. The bioactive component-target network of "SYD" was constructed by Cytoscape. Also, we constructed a PPI (protein-protein interaction) network using the Search Tool for the Retrieval of Interacting Genes Database (STRING) to identify the potential SYD targets for the treatment of HZ. "ClusterProfiler" in R-project was used for Gene Ontology (GO) analysis and KEGG pathway enrichment analysis. The SYD hub genes were screened by component-target network topological parameters, and the findings confirmed by molecular docking.
Results We selected 126 bioactive components and 235 targets. By assessing the topological parameters of degree network, we identified five hub genes related to SYD based therapy against HZ, that is, CDK2, CASP3, JUN, AKT1, and MAPK1. According to the results of enrichment analysis, the treatment of HZ with SYD mainly involved toll-like receptor signaling, C-type lectin receptor, MAPK, PI3K-Akt, and other signal pathways. The results of molecular docking analysis showed that the binding energy between SYD bioactive compounds and hub targets was good.
Conclusion The results showed that SYD is effective in the treatment of HZ through multi-target and multi-pathway. It provides certain theoretical support for SYD treatment of HZ and a new direction for the treatment of HZ by traditional Chinese medicine.

Keywords
Herpes zoster, Simiao Yongan Decoction, Network pharmacological, Molecular docking

Cite this paper
Lusheng Huang, Shuangshuang Hu, Simiao Yongan Decoction in Treating Herpes Zoster: A Network Pharmacology- Based study , SCIREA Journal of Clinical Medicine. Volume 7, Issue 2, April 2022 | PP. 65-85. 10.54647/cm32778

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