Abstract
Introduction:Short stature is one of the most common causes of referral to the endocrinology and pediatric clinics and in most cases is due to normal variants of growth such as familial short stature or constitutional growth delay, but it may be due to some treatable and important diseases. In this study we investigate the causes of short stature in children and adolescents. Material and Method: Every child or adolescent under 18 years old with height below 3rd percentile of growth charts, referred pediatric endocrinology clinic, included to the study. The height and weight of the children and their parents were measured and physical examination was done in order to find the cause of short stature. For all children a set of routine lab data performed. The left hand x-ray of each child was taken to determine the bone age and for evidences of bone dysplasia. Growth hormone stimulation test applied if there was any indication for this test.Result: A total of 363 child and adolescent (173 male, 190 female) with short stature were studied. The more common causes of short stature included: familial short stature 39.9% (112 person), constitutional growth delay 26.4% (96 person), growth hormone deficiency 9.1% (34 person). The less common causes of short stature included: hypopitutarism , hypothyroidism , achondroplasia ,hypochondroplasia, Addison disease, cancer, chronic hepatitis, congenital ichtiosis, cystic fibrosis, cystinosis, Down syndrome and etc. Conclusion: The most common cause of short stature in both sex was a normal variance followed by growth hormone deficiency. Less common but treatable causes should be always in differential diagnosis.

Keywords
Short stature, Growth, Constitutional growth delay, Familial Short stature, Children

Cite this paper
Kobra Shiasi Arani, Sedighe Asgarian, Etiology of short stature in children and adolescents , SCIREA Journal of Clinical Medicine. Volume 1, Issue 1, October 2016 | PP. 75-85.

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