Viruses and genetics in pregnancy and birth

Volume 8, Issue 5, October 2023     |     PP. 138-158      |     PDF (535 K)    |     Pub. Date: October 30, 2023
DOI: 10.54647/biology180326    56 Downloads     98935 Views  

Author(s)

Čulić Vida, Gynecology and Obstetrics Private Outpatient Clinic, Split, Croatia; Laboratory for Human Genetics, Department of Medical Genetics, Pediatrics Clinic, University Hospital Centre Split, Split, Croatia
Robert Vulić, Gynecology and Obstetrics Private Outpatient Clinic, Split, Croatia
Maja Radman, Clinics for Internal Medicine, Department of Endocrinology, Diabetes and Metabolism, University Hospital Center Split, Split, Croatia
Tamara Bošnjak, Neonatology Department, Clinics for Gynecology and Obstetrics, University Hospital Centre Split, Split, Croatia
Jasminka Rešić Karara, Clinics for Gynecology and Obstetrics, University Hospital Centre Split, Split, Croatia
Maria Lopatkina, Research Institute of Medical Genetics, Tomsk National Research Medical Center, Tomsk, Russia
Igor Lebedev, Research Institute of Medical Genetics, Tomsk National Research Medical Center, Tomsk, Russia

Abstract
In this study we presented several patients with genital infections during pregnancy, perinatal infection, de novo genetics syndromes, sterility problems and spontaneous abortions with HSV1, HSV2, CMV, Adeno, Parvo B19, RSV, EBV and Coxsackie virus. Spontaneous abortion were provoked (or at least associated) with viral infection. For some we had expected such pregnancy outcomes, and for some we observed chromosome breaks that by repetitive screening, after cessation of acute viral infection, could no longer been seen. Nonspecific chromosomal aberrations were associated with HSV type 2, herpes zoster and Ebstein Barr virus infection.
EBV is a causative agent of autoimmune entities were polyclonality in serological findings is present, we are searching for the same answer in the cause of spontaneous abortion with or without chromosomes abnormalities with atypical serology values of those viruses at both partners.

Keywords
chromosome breakage, viruses, perinatal infections, spontaneous abortions

Cite this paper
Čulić Vida, Robert Vulić, Maja Radman, Tamara Bošnjak, Jasminka Rešić Karara, Maria Lopatkina, Igor Lebedev, Viruses and genetics in pregnancy and birth , SCIREA Journal of Biology. Volume 8, Issue 5, October 2023 | PP. 138-158. 10.54647/biology180326

References

[ 1 ] Silasi, M.; Cardenas, I.; Racicot, K.; Kwon, Ja-Y.; Racicot, K.; Aldo, P.; and Mor, G. Viral infections during pregnancy. Am J Reprod Immunol 2015,73(3):199-213. doi:10.1111/aji.12355.
[ 2 ] Waldorf, KMA and McAdams, RM. Influence of infection during pregnancy on fetal development. Reproduction. 2013,146(5):R151–R162. doi: 10.1530/REP-13-0232.
[ 3 ] Pereira, L. Congenital viral infection: transversing the uterine-placental interface. Ann Rev Virol. 2018,(5):273-299.  doi: 10.1146/annurev-virology-092917-043236.
[ 4 ] Challis, JR.; Lockwood, CJ.; Myatt, L.; Norman, JE.; Strauss, JF 3rd.; Petraglia, F. Inflammation and pregnancy. Reprod Sci. 2009,16(2):206-215.doi: 10.1177/1933719108329095.
[ 5 ] Revello, MG.; Zavattoni, M.; Furione, M.; Lilleri, D.; Gorini, G. and Gerna, G. Diagnosis and outcome of preconceptional and periconceptional primary human cytomegalovirus infections. J Infect Dis 2002,186(4):553–557. doi: 10.1086/341831.
[ 6 ] Bolis, V.; Karadedos, C.; Chiotis, I.; Chaliasos, N.; Tsabouri, S. Atypical manifestations of Epstein-Barr virus in children: a diagnostic challenge. J Pediatr (Rio J). 2016,92(2):113-121. doi.org/10.1016/j.jped.2015.06.007. 
[ 7 ] Middeldorp, JM. Epstein-Barr virus-specific humoral immune responses in health and disease. Curr Top Microbiol Immunol. 2015,391:289-323. doi: 10.1007/978-3-319-22834-1-10.
[ 8 ] De Paschale, M.; Clerici, P. Serological diagnosis of Epstein-Barr virus infection: Problems and solutions. World J Virol. 2012,1(1):31-43.
[ 9 ] Dell’Aquila, ML.; Fortunato, EA. and Spector, DH. Viral induction of site-specific chromosome damage. Rev Med Virol. 2003;13(1):21-37.doi: 10.1002/rmv.368.
[ 10 ] Arbuckle, JH.; Medveczky, MM.; Luka J Hadleya, SH.; Luegmayrc, A.; Ablashid, D.; Lunde, TL.; Tolare, J.; De Meirleirf, K.; Montoyag, JG.; Komaroffh, AL.; Ambrosc, PF. and Medveczky, PG. The latent human herpesvirus-6A genome specifically integrates in telomeres of human chromosomes in vivo and in vitro. PNAS. 2010,107(12):563-5563-5568. doi:10.1073/pnas.0913586107.
[ 11 ] Gruhne, B.; Sompallae, R.; Marescotti, D.; Kamranvar, SA.; Gastaldello, S.; Masucci, MG. The Epstein–Barr virus nuclear antigen-1 promotes genomic instability via induction of reactive oxygen species.  PNAS. 2009,106(7):2313-2318. doi: 10.1073/pnas.0810619106.
[ 12 ] Weitzman, MD.; Lilley, CE.; Chaurushiya, M. Genomes in conflict: maintaining genome integrity during virus infection. Ann Rev Microbiol. 2010,64(1):61-81 doi: 10. 1146/annurev. micro.112408.134016S.
[ 13 ] Skryabin, N.A.; Vasilyev, S.A.; Nikitina, T.V.; Zhigalina, D.I.; Savchenko, R.R.; Babushkina, N.P.; Lopatkina, M.E.; Kashevarova, A.A.; Lebedev, I.N. Runs of homozygosity in spontaneous abortions from families with recurrent pregnancy loss. Vavilov J Genet Breed 2019,23(2):244-249. doi10.18699/VJ19.489.
[ 14 ] Al-Buhtori, M.; Moore L.; Benbow, EW. and Cooper, RJ. Viral Detection in Hydrops Fetalis, Spontaneous Abortion, and Unexplained Fetal Death In Utero. Journal of Medical Virology.2011, 83:679-684.
[ 15 ] Rasti, S.; Ghasemi, FS.; Abdoli, A.; Piroozmand, A.; Gholam, S.; Mousavi, A. and Fakhrie-Kashan, Z. ToRCH “co-infections” are associated with increased risk of abortion in pregnant women. Congenital Anomalies 2016,56;73:78–73.doi:10.1111/cga.12138.
[ 16 ] Kamranvar, SA.; Gruhne, B.; Szeles, A. and Masucci, MG. Epstein–Barr virus promotes genomic instability in Burkitt’s lymphoma. Oncogene. 2007,26:5115–5123.
[ 17 ] Viswanathan, GR. and Sapkal, GN. Molecular aspects of the teratogenesis of rubella virus. Biol Res 2019,52:47.https://doi.org/10.1186/s40659-019-0254-3.
[ 18 ] Chentoufi, AA.; Dervillez, X.; Dasgupta, G. et al. The Herpes Simplex Virus Type 1 Latency-Associated Transcript Inhibits Phenotypic and Functional Maturation of Dendritic Cells. Viral Immunology 2012,25(3):204-215.doi:10.1089.
[ 19 ] Zhou, Ya.; Bian, G.; Zhou, Q.; Gao, Z.; Liao, P.; Liu, Y; He, M. Detection of cytomegalovirus, human parvovirus B19, and herpes simplex virus-1/2 in women with first-trimester spontaneous abortions. J Med Virol 2015,87(10):1749-53.doi: 10.1002/jmv.24218. 
[ 20 ] Fowler, KB.; Stagno, S.; Pass, RF. Maternal Immunity and Prevention of Congenital Cytomegalovirus Infection Volume. JAMA 2003,289(8) 26 p 1008–1011.
[ 21 ] Levy, R.; Najioullah, F.; Keppi, B.; Thouvenot, D.; Bosshard, S.; Lornage, J.; Lina, B.; Guerin, JF.; Aymard, M. Detection of cytomegalovirus in semen from a population of men seeking infertility evaluation. Fert Ster 1997,(68)5:820-825. https://doi.org/10.1016/S0015-0282(97)00340-3.
[ 22 ] Numazaki, K.; Fujikawa, T.; Chiba, S. Relationship between seropositivity of husbands and primary cytomegalovirus infection during pregnancy. J Infect Chemother 2000,6(2):104-6. DOI: 10.1007/pl00012146
[ 23 ] Michou, V.; Liarmakopoulou, S.; Thomas, D.; Tsimaratou, K.; Makarounis, P.; , R.; Angelopoulou, V.; Tsilivakos. Herpes virus infected spermatozoa following density gradient centrifugation for IVF purposes. Andrologia 2012,44(3):174-80.doi: 10.1111/ j. 1439-0272.2010.01121.
[ 24 ] Voon-Kwan Siew; Chang-Yih Duh and Shang-Kwei Wang. Human cytomegalovirus UL76 induces chromosome aberrations. Journal of Biomedical Science 2009,16:107.
[ 25 ] Gao, L.; Liu, YH.; Li LF.; Wu, Y.; Wang, M.; Shi, J.; Yuan, B.; Song, J.; He, Y.; Wei D. Changes of peripheral blood chromosomal centromere aberration in patients with cytomegalovirus infection after anti-viral treatment. (Article in Chinese) Nan Fang Yi Ke Da Xue Xue Bao 2009,29(9):1846-7.
[ 26 ] Quaglia, M.; Mwrlotti,G.; De Andrea, M.; Borgogna, C.; Cantaluppi,V. Viral Infections and Systemic Lupus Erythematosus: New Players in an Old Story. Viruses 2021,11;13(2):277.doi: 10.3390/v13020277.
[ 27 ] Jordan, JA. and Butchko, AR. Apoptotic Activity in Villous Trophoblast Cells During B19 Infection Correlates with Clinical Outcome: Assessment by the Caspase-related M30. Cyto Placenta 2002,(23):547–553doi:10.1053.
[ 28 ] Klenerman, P.; Tolfvenstam, T.; Price, DA.; Nixon, DF.; Broliden, K.; Oxenius, A. T lymphocyte responses against human parvovirus B19: small virus, big response. Pathol Biol 2002,50:317-25.
[ 29 ] von Landenberg, Ph.; Lehmann, HW.; Knoll, A.; Dorsch, S. and Modrow,S. Antiphospholipid Antibodies in Pediatric and Adult Patients With Rheumatic Disease Are Associated With Parvovirus B19 Infection. Arthritis Rheum 2003,48(7):1939-47.doi: 10.1002/art.11038.
[ 30 ] Mamedalieva, NM.; Kurmanova, AM.; Moshkalova, GN.; Kim, V. Local immunity status in patients with miscarriages and herpetic infection. Gynecol Endocrinol 2016,32(sup2):45-46.doi: 10.1080/09513590.2016.1232772.
[ 31 ] Makhseed, M.; Raghupathy, R.; Azizieh, F.; Farhat, R.; Hassan, N. and Bandar,A. Circulating cytokines and CD30 in normal human pregnancy and recurrent spontaneous abortions. Hum Reprod 2000,15;9:2011–2017.doi.org/10.1093/humrep/15.9.2011.
[ 32 ] Agut, H.; Bonnafous, P.; Gautheret-Dejean, A. Laboratory and Clinical Aspects of Human Herpesvirus 6 Infections.Clin Microbiol Rev 2015,(28)2.doi:10.1128/CMR.00122-14.
[ 33 ] Gruhnea, B.; Sompallaea, R.; Marescottia, D.; Kamranvara, SA.; Gastaldelloa, S. and Masuccia, MG. The Epstein–Barr virus nuclear antigen-1 promotesgenomic instability via induction of reactive oxygen species. PNAS 2009,(106) 7: 2313–2318. doi:10.1073/ pnas. 0810619106.
[ 34 ] Dirmeier, U.; Hoffmann, R.; Kilger, E.;  Schultheiss, U.; Briseño, C.; Gires, O.; Kieser, A.; Eick, D.; Sugden, B.; Hammerschmidt, W. Latent membrane protein 1 of Epstein–Barr virus coordinately regulates proliferation with control of apoptosis. Oncogene 2005, 24:1711–1717. doi:10.1038/sj.onc.1208367.
[ 35 ] Altmann, M. and Hammerschmidt W. Epstein-Barr Virus Provides a New Paradigm: A Requirement for the Immediate Inhibition of Apoptosis. PLoS Biol 2005,3(12): e404.
[ 36 ] McKenzie, J.; El-Guindy, A. Epstein-Barr Virus Lytic Cycle Reactivation. Curr Top Microbiol Immunol 2015, 391:237-61. doi: 10.1007/978-3-319-22834-1-8.
[ 37 ] Sinclair, AJ. Unexpected structure of Epstein–Barr virus lytic cycle activator Zta. Trends in Microbiology 2006, (14),7:289-291. doi: 10.1016/j.tim.2006.05.003.
[ 38 ] Bernasconi, NL.; Traggiai, E.; Lanzavecchia, A. Maintenance of Serological Memory by Polyclonal Activation of Human Memory B Cells. Science 2002, 298(5601):2199-2202. doi: 10.1126/science.1076071.
[ 39 ] Lin, Z.; Yin Q. and Flemington, E. Identification of a Negative Regulatory Element in the Epstein-Barr Virus Zta Transactivation Domain That Is Regulated by the Cell Cycle Control Factors c-Myc and E2F1. J Virol 2004,78(21):11962-11971.doi: 10.1128/JVI.78.21.11962-11971.
[ 40 ] A Szymula, A.; Palermo, RD.; Bayoumy, A.; Groves, IJ.;  Abdullah, MB.; Holder, B.; White, RE. Epstein-Barr virus nuclear antigen EBNA-LP is essential for transforming naïve B cells, and facilitates recruitment of transcription factors to the viral genome. PLOS Pathogens 2018, 14(2):doi.org/10.1371/journal.ppat.1006890
[ 41 ] Varıcı Balcı, FK.; Özbek, OA.; Sayıner, AA. Atypical profile problem in serological diagnosis of EBV. [Article in Turkish]. Mikrobiyoloji bülteni 2017,51(4):378-386 DOI: 10.5578/mb.58662.
[ 42 ] Abrahamyan, S.; Eberspächer, B.; Hoshi, MM.; Aly, L.; Luessi, F.; Groppa, S.; Klotz, L.; Meuth, SG.; Schroeder, Ch.; Grüter, T.; Tackenberg, B.; Paul, F.; Then- Bergh, F.; Kümpfel, T.; Weber, F.; Stangel, M.; Bayas, A.; Wildemann, B.; Heesen, Ch.; Zettl, U.; Warnke, C.; Antony, G.; Hessler, N.; Wiendl, H.; Bittner, S.; Hemmer, B.; Gold, R.; Salmen, A.; Ruprecht, K. (KKnMs). Complete Epstein-Barr virus seropositivity in a large cohort of patients with early multiple sclerosis. J Neurol Neurosurg Psychiatry 2020, 0:1–6. doi:10.1136/jnnp-2020-322941
[ 43 ] Sompallae, R.; Callegari, S.; Kamranvar, SA.; Masucci, MG. Transcription Profiling of Epstein-Barr Virus Nuclear Antigen (EBNA)-1 Expressing Cells Suggests Targeting of Chromatin Remodeling Complexes. PLoS One 2010,10;5(8):e12052.doi: 10.1371/journal.pone.0012052.
[ 44 ] Martínez-A C. and van Wely, KHM. Are aneuploidy and chromosome breakage caused by a CINgle mechanism? Cell Cycle 2010, 9:12:2275-2280.doi:10.4161/cc.9.12.11865.
[ 45 ] Li,Ch.; Shi, Z.; Zhang, L.; Huang, Y.; Liu, A.; Jin, Y.;  Yu, Y.; Bai, J.; Chen, D.; Gendron, Ch.; Liu, X.; Fu, S. Dynamic changes of territories 17 and 18 during EBV-infection of human lymphocytes. Mol Biol Rep 2010,37(5):2347-54. doi: 10.1007/s11033-009-9740-y.
[ 46 ] Gruhne, B.; Sompallae, R. and Masucci, MG. Three Epstein-Barr virus latency proteins independently promote genomic instability by inducing DNA damage, inhibiting DNA repair and inactivating cell cycle checkpoints Genomic instability in EBV-infected cells. Oncogene 2009, 28:3997-4008 doi:10.1038/onc.2009.258.
[ 47 ] Tarek, AA. Overview of genetic causes of recurrent miscarriage and the diagnostic approach. BIOCELL 2019,43(4):253-262. doi:10.32604/biocell.2019.08180.
[ 48 ] Wang, Sh.; Liu, Y.; Shang,Y.;  Zhai, B.;   Xiao Yang , X.; Kleckner, N.; Zhang, L.Crossover Interference, Crossover Maturation and Human Aneuploidy. Bioessays 2019, 41(10):e1800221. doi:10.1002.
[ 49 ] Wei, A; Multi, S.; Yang, CR.; Ma, J.; Zhang,QH.; Wang, ZB.; Li,M.; Wei, L.; Gr, ZJ.; Zhang, ChH.; Ouyang, YCh.; Hou, Y.; Schatten, H.; Qing-Yuan Sun, QY. Spindle Assembly Checkpoint Regulates Mitotic Cell Cycle Progression during Preimplantation Embryo Development. PLoS ONE 2011,6(6):e21557. doi:10.1371/journal.pone.0021557.
[ 50 ] Jauniaux, E.; Poston, L.; Burton, GJ. Placental-related diseases of pregnancy: involvement of oxidative stress and implications in human evolution. Hum Reprod Update 2006,(12),6:747–755.doi: 10.1093/humupd/dml016.
[ 51 ] de Lima Kaminski, V.; Ellwanger, JH.; Bogo Chies, JA. Extracellular vesicles in host-pathogen interactions and immune regulation-exosomes as emerging actors in the immunological theater of pregnancy. Heliyon 2019, 5:e02355.doi: 10.1016/j.heliyon.2019.e02355.
[ 52 ] Racicot, K and Mor, G. Risks associated with viral infections during pregnancy. JCI 2017, (127) 5,1591-99. doi: 10.1172/JCI87490.
[ 53 ] Tolmacheva, EN.; Vasilyev, SA. and Lebedev, IN. Aneuploidy and DNA Methylation as Mirrored Features of Early Human Embryo Development. Genes 2020,11:1-21.1084; doi:10.3390/genes11091084
[ 54 ] Kashevarova, AA.; Tolmacheva, EN.; Sazhenova, EA.; Sikhanova, NN.; Lebedev IN. [Methylation profiling of the cell cycle regulating genes in placenta of human embryos with chromosomal mosaicism]. Mol Biol (Mosk) 2011,45(2):316-24. Russian. PMID: 21634119.