Comparative study on hepatotoxic effect of paracetamol, Lead and Arsenic: Analysis, Evaluation and Treatment solution

Volume 8, Issue 1, February 2024     |     PP. 1-11      |     PDF (161 K)    |     Pub. Date: January 2, 2024
DOI: 10.54647/pmh330318    22 Downloads     630 Views  

Author(s)

Ambreen Siddique, Department of Pharmacology, Islamia University Bahawalpur.

Abstract
Background: Paracetamol, lead, and arsenic are substances known for their potential hepatotoxic effects. Paracetamol overdose can lead to severe liver damage, while lead and arsenic, heavy metals commonly found in the environment, have been associated with liver toxicity upon exposure. Understanding the comparative effects of these substances on liver function and identifying effective treatment solutions are crucial for mitigating their toxic impact.
Objective: The objective of this research article is to conduct a comparative study on the hepatotoxic effects of paracetamol, lead, and arsenic, analyze their impact on liver function, and propose treatment solutions to alleviate liver damage. The study aims to assess the differential effects of these substances using in vitro and in vivo models, evaluate liver function markers, and explore potential treatment strategies for liver protection and regeneration.
Method: This study employs in vitro and in vivo approaches to investigate the hepatotoxic effects of paracetamol, lead, and arsenic. Hepatocyte cultures will be exposed to varying concentrations of these substances in vitro, while animal models will be treated with controlled doses in vivo. Liver function markers, including liver enzyme levels, oxidative stress markers, histopathological analysis, and gene expression profiling, will be measured to assess the impact on liver health.
Result: The comparative analysis reveals distinct hepatotoxic effects of paracetamol, lead, and arsenic on liver function. Paracetamol overdose induces liver damage primarily through oxidative stress and inflammation pathways. Lead exposure leads to impaired liver function, manifested by altered liver enzyme levels and histopathological changes. Arsenic exposure causes liver toxicity through oxidative stress, DNA damage, and altered gene expression. The comparative analysis also highlights potential synergistic effects or interactions among these substances.
Conclusion: This research article proposes effective treatment solutions to mitigate the hepatotoxic effects of paracetamol, lead, and arsenic. Antioxidant supplementation demonstrates potential as a protective measure against paracetamol-induced liver damage. Chelation therapy shows promise in mitigating the toxic effects of lead, while dietary interventions and pharmacological approaches targeting specific molecular pathways could help alleviate arsenic-induced liver toxicity. These findings contribute to a better understanding of liver toxicity mechanisms caused by these substances and provide evidence-based strategies for preventing and managing liver damage associated with paracetamol overdose, lead exposure, and arsenic contamination.

Keywords
Hepatotoxic effects, paracetamol, lead and arsenic

Cite this paper
Ambreen Siddique, Comparative study on hepatotoxic effect of paracetamol, Lead and Arsenic: Analysis, Evaluation and Treatment solution , SCIREA Journal of Health. Volume 8, Issue 1, February 2024 | PP. 1-11. 10.54647/pmh330318

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