The Challenges and Solutions of Chiral Drug Preparation Techniques

Volume 9, Issue 1, February 2024     |     PP. 12-22      |     PDF (167 K)    |     Pub. Date: January 16, 2024
DOI: 10.54647/chemistry350041    29 Downloads     100577 Views  


Zhao Mingrui, College of Pharmacy, Henan Medical College, Zhengzhou,451191, China
Shi Xiufang, School of Pharmaceutical Sciences, Zhengzhou University, Henan, Zhengzhou 450000, China
Yang Ninghui, College of Pharmacy, Henan Medical College, Zhengzhou,451191, China

To explore the challenges faced by chiral drug preparation techniques and propose corresponding solutions, We introduce the background and significance of chiral drug preparation technology, Subsequently, we analyze in detail various challenges faced in the current preparation of chiral drugs, including selectivity in asymmetric synthesis, substrate conversion rate, and catalyst selection. In order to address these challenges, a series of solutions, including the use of novel catalysts, optimization of reaction conditions, and improvements in reaction processes were proposed. Through the application of these solutions, various difficulties in the process of chiral drug preparation were successfully overcome, achieving efficient and selective synthesis. The discoveries of these research findings have important theoretical and practical implications for the preparation of chiral drugs and pharmaceutical development. In future research, we will continue to improve chiral drug preparation techniques to enhance synthesis efficiency and yield, at the same time, to meet the demands for drug therapy. In conclusion, this paper provides a detailed exploration of the challenges and solutions in chiral drug preparation technology, offering valuable references for research in this field.

Chiral Drug Preparation Techniques, Challenges, Solutions, Chiral Drug

Cite this paper
Zhao Mingrui, Shi Xiufang, Yang Ninghui, The Challenges and Solutions of Chiral Drug Preparation Techniques , SCIREA Journal of Chemistry. Volume 9, Issue 1, February 2024 | PP. 12-22. 10.54647/chemistry350041


[ 1 ] Zhang Shengyong, Jiang Ru, He yi, etal. Asymmetric catalytic synthesis of chiral drugs: opportunities and challenges[J].Journal of Air Force Medical University:1-19.
[ 2 ] Chiral Graphene Quantum Dots Enhanced Drug Loading into Exosomes.bioRxiv,2023
[ 3 ] Chiral Graphene Quantum Dots Enhanced Drug Loading into Small Extracellular Vesicles. ACS Nano,2023
[ 4 ] Fang Zhengyu, Xing Cheng, Hu Kun, etal. Research progress in chiral drug resolution reagents[J], China Pharmacist2021,24(2)
[ 5 ] Cubosomes in Drug Delivery—A Comprehensive Review on Its Structural Components, Preparation Techniques and Therapeutic Applications.Biomedicines,2023,11
[ 6 ] CAO Yang, Zhu Ranran, Ou Xingjun, etal. Recent Advances in Resolution of Chiral Drugs Based on Cocrystallization [J]. Chinese Journal of Pharmaceuticals 2023, 54(10):1420-1428. DOI:10.16522/j.cnki.cjph.2023.10.003.
[ 7 ] Peter E. Feist, A. Hummon. Proteomic Challenges: Sample Preparation Techniques for Microgram-Quantity Protein Analysis from Biological Samples. International Journal of Molecular Sciences,2015,16:3537 - 3563
[ 8 ] V. V. S. P. Kumari Rayala, Jony Susanna Kandula, Radhakrishnanand P. Advances and challenges in the pharmacokinetics and bioanalysis of chiral drugs. Chirality, 2022
[ 9 ] Yang Zehui,Huang Lian,Song Dingguo,etal.Progress in industrial-scale transition metal catalytic enantioselective synthesis[J].Chinese Journal of pharmaceutical industry,2023,54(06):835-858.DOI:10.16522/j.cnki.cjph.2023.06.003.
[ 10 ] Teng Jinkui. Construction of amino acid-derived arene nanoparticles and their selective capture and release of chiral drugs[D]. Yunnan Normal University,2023. DOI:10.27459/d.cnki.gynfc.2023.001678.
[ 11 ] Ge P, Liu N, Jin X W,eta1. Chiral pharmaceuticals in aquatic environments:Occurrence,fate,toxicity,and ecological risk[J].Asian Journal of Ecotoxicology,2023,18(1):191—205(in Chinese)
[ 12 ] Zhang Wenhe,Zhu Tianhui,Qin Fengyu,etal.Application of biocatalysis in chiral drug synthesis[J].Biotechnology for the biological industry,2019(03):54-68.
[ 13 ] Yan Ming,Organic catalytic synthesis of GABA chiral drugs[D]. Guangzhou:Sun Yat-sen University,2020-09-16.
[ 14 ] Liang Xiao,Li Yalan, Bai Haotian, etal. Advances in drug delivery systems based on nanocarriers for Rheumatoid Arthritis therapy[J].China Journal of Chinese Materia Medica,2023,48(18):4874-4883.DOI:10.19540/j.cnki.cjcmm.20230614.601.
[ 15 ] Li Junyan,Wang Wenping,Zhang Yi,etal. Research progress of vesicles derived from Chinese herbal medicines[J].Journal of Zhejiang University(Medical Sciences),2023,52(03):349-360.
[ 16 ] Lei Ziwen,Qi Yingqiu,Nie Guangjun.Nano-biomaterials: help develop anti-cancer drugs[J].Science,2023,75(05):17-19+24+21-22+69.
[ 17 ] Xu Yinsheng, Ren Xiangyu, Yu Mengzhen, etal. Nanotechnology-based drug delivery strategies and their applications in cancer therapy[J]. Chinese Science Bulletin,2023,68(32):4346-4372.
[ 18 ] Fan Ronghui, Yang Zhiqiang, Li Boshen, etal. Research progress on brain diseases treated by TCM nanotechnology[J].Chinese Journal of Comparative Medicine,2023,33(06):128-140.
[ 19 ] Shi Qiang. Preparation of gold nano-sensor and its application in visual detection of drug residues[D]. Yangzhouuniversity,2023. DOI:10.27441/d.cnki.gyzdu.2023.002604.
[ 20 ] Yan Jiahui. Preparation of cationic lipid nanoparticles[D]. Beijing university of chemical technology,2023.DOI:10.26939/d.cnki.gbhgu.2023.000394.