Development Trends in Chiral Drug Synthesis Techniques

Volume 9, Issue 1, February 2024     |     PP. 1-11      |     PDF (330 K)    |     Pub. Date: January 9, 2024
DOI: 10.54647/chemistry150337    39 Downloads     100573 Views  

Author(s)

Zhao Mingrui, College of Pharmacy, Henan Medical College, Zhengzhou, China
Xu Zhanhui, College of Chemistry, Zhengzhou University,Zhengzhou, China
Yang Ninghui, College of Pharmacy, Henan Medical College, Zhengzhou, China

Abstract
The research and application of chiral drugs has attracted increasing attention, to explore the development trends of chiral drug synthesis technology,this paper introduce related green chemistry and emerging technologies, elaborates on the application of green chemistry in chiral drug synthesis, including catalyst design and utilization, solvent selection, and waste management. These green chemistry methods can significantly reduce environmental pollution and resource consumption, improve synthesis efficiency, and make chiral drug synthesis more sustainable and efficient. At the same time, this paper also introduces the application of some emerging technologies and equipment in chiral drug synthesis. These emerging technologies include microfluidic technology, electrochemical synthesis, solid-phase synthesis, and so on. The application of these technologies and equipment can effectively improve the synthesis efficiency and yield of chiral drugs, and have stronger controllability and selectivity. In addition, important experimental devices and instruments such as stereoisomers and nanoscale catalysts are also introduced, which provide effective tools and methods for chiral drug synthesis research. In summary, this paper systematically studies and summarizes the development trends of chiral drug synthesis technology. Through the application of green chemistry and emerging technologies, providing important guidance and reference for the research and application of chiral drugs. This research has important scientific significance and application value in promoting the development and innovation of chiral drugs.

Keywords
Chiral Drug Synthesis Techniques, Development Trends, Chiral Drug

Cite this paper
Zhao Mingrui, Xu Zhanhui, Yang Ninghui, Development Trends in Chiral Drug Synthesis Techniques , SCIREA Journal of Chemistry. Volume 9, Issue 1, February 2024 | PP. 1-11. 10.54647/chemistry150337

References

[ 1 ] Emerging Developments in Separation Techniques and Analysis of Chiral Pharmaceuticals.Molecules,2023,28
[ 2 ] P. Ferreira, D. Arcanjo, A. Peron. Drug development, Brazilian biodiversity and political choices: Where are we heading? Journal of Toxicology and Environmental Health. Part B, Critical Reviews,2023,26:257 - 274
[ 3 ] Skipped Fluorination Motifs: Synthesis of Building Blocks and Comparison of Lipophilicity Trends with Vicinal and Isolated Fluorination Motifs. Journal of Organic Chemistry,2021
[ 4 ] Chiral stationary phases and applications in gas chromatography. Chirality,2022
[ 5 ] Zhou Qilin, Asymmetric catalytic kinetic resolution and its application[J]. Tianjin, Nankai University ,2020-12-29.
[ 6 ] T. Sudha. Chemistry and euro green chemistry recent trends in the separation of chiral drugs.2019
[ 7 ] Zhou Qilin, Highly efficient asymmetric catalytic reactions and their applications in the synthesis of natural products and chiral drugs[J], Tianjin,Nankai University,2015-04-24.
[ 8 ] Youfang Huang, Yanyun Li, Yuanfei Wu, etal. Computer-aided design-based green fabrication of magnetic molecularly imprinted nanoparticles for specific extraction of non-steroidal anti-inflammatory drugs[J]. Chemical Engineering Journal 452(2023)139440
[ 9 ] Fu Qiang. Research and implementation of a microfluidic device for rapid detection of nucleic acids[D]. Beijing university of chemical technology,2023. DOI:10.26939/d.cnki.gbhgu.2023.000321.
[ 10 ] Du Peng, Zhou Qingzhong, Zheng Hanwen,etal. Research progress of microchannel cooling technology for high-density integrated microsystems[J]. Microelectronics & Computer,2023(01):87-96 https://doi.org/10.19304/J.ISSN1000-7180.2022.0810.
[ 11 ] Yang Yuchi, Lv Peiyu,Du Jianyu,etal. Embedded microfluidic cooling technology for large area processing chip[J]. Microelectronics & Computer,2023(01):105-123 https://doi.org/10.19304/J.ISSN1000-7180.2022.0765.
[ 12 ] Sun Yilan, Zang Xiaofeng, Liu Yinghui, etal.Progress in materials selection for flexible electrochemical sensors[J].Journal of composite materials:1-11. https://doi.org/10.13801/j.cnki.fhclxb.20231205.002.
[ 13 ] Gao Ruilin, Wen Lirong, Guo Weisi.Advances in electrochemical promotion of functionalization of unactivated C (SP ~ 3)-H[J]. Organic chemistry:1-16. http://kns.cnki.net/kcms/detail/31.1321.O6.20231130.1504.004.html.
[ 14 ] Li jiaming, Meng Xiaorong, Wu Zhenpeng. High stability LiAl0.1MN1.9O4 was used to extract lithium from electrochemical brine[J].Chemical Industry and engineering:1-12. https://doi.org/10.13353/j.issn.1004.9533.20230160.
[ 15 ] Hui Chenke, Yan Lingpeng, Yang Weipeng, etal. Progress in the application of graphene aerogel composites in electrochemical energy storage[J].Journal of composite materials:1-16. https://doi.org/10.13801/j.cnki.fhclxb.20231115.001.
[ 16 ] Yu Dazhao, Zhang Tong, Liu Qi. The corrosion deposition distribution of H62 copper alloy was studied based on the level set method[J]. Journal of Ordnance Equipment Engineering,2021,42(07):263-268.
[ 17 ] Zhang Han, Wang Yonglong, Zhang Bo, etal. Nitrogen-doped carbon nanotubes encapsulated with Ni-doped FEP nanoparticles were used as bifunctional electrocatalysts[J]. Science China(Materials),2023,66(12):4630-4638.
[ 18 ] Cao Zeyu, Zhang Xin’ai, Zhang Bo, etal. Study on electrocatalytic reduction of CO2 over MOF-based Ni-N-C catalyst regulated by Ni nanoparticles[J].Modern Chemical Industry:1-15. http://kns.cnki.net/kcms/detail/11.2172.TQ.20231129.1346.020.html.
[ 19 ] Zhang Shengyong, Jiang Ru, He yi, etal. Asymmetric catalytic synthesis of chiral drugs: opportunities and challenges[J].Journal of Air Force Medical University:1-19. http://kns.cnki.net/kcms/detail/61.1526.R.20231120.1306.004.html.
[ 20 ] Zhu Jing, He Huan, Jiang Xuefeng. Concepts and objectives in scientific research: Ericsson and the field of Enantioselective synthesis[J]. Chinese Journal of Chemical Education,2023,44(19):1-14. DOI:10.13884/j.1003-3807hxjy.2023090084.