Volume 3, Number 3 (2019)
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Home > Journals > SCIREA Journal of Health > Archive > Paper Information

PIROXICAM MAY CAUSE PARKINSONISM IN HUMANS: A MINI REVIEW

Volume 3, Issue 3, June 2019    |    PP. 62-69    |PDF (146 K)|    Pub. Date: July 15, 2019
46 Downloads     379 Views  

Author(s)
Dr. Saganuwan Alhaji Saganuwan, Department of Veterinary Physiology, Pharmacology and Biochemistry, College of Veterinary Medicine, University of Agriculture, P.M.B. 2373, Makurdi, Benue State, Nigeria.

Abstract
Parkinsonism is a neuro-degenerative disease caused by destruction or impairment of basal ganglia which secretes dopamine from dopaminergic nerve that is connected to cholinergic nerve that secretes acetylcholine leading to decreased level of dopamine production. Piroxicam when administered to monogastric animals caused Parkinson-like effects characterize by opistothonus, torticollis, hypotention and sedation which are extrapyramidal. Therefore piroxicam may cause damage to basal ganglia resulting cholinergic effect. However, hydroxylated and carboxybenzothiazine metabolites of piroxicam must have been responsible for dopaminergic effect similar to that of fluphenazine in dose-dependent fashion.

Keywords
Piroxicam, parkinsonism, acetylcholine, dopamine, basal ganglia

Cite this paper
Dr. Saganuwan Alhaji Saganuwan, PIROXICAM MAY CAUSE PARKINSONISM IN HUMANS: A MINI REVIEW, SCIREA Journal of Health. Vol. 3 , No. 3 , 2019 , pp. 62 - 69 .

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