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Home > Journals > SCIREA Journal of Pharmacy > Archive > Paper Information

METABOLIC COMFORT IN ONCOLOGY AND FREE AMINO ACIDS: PERSPECTIVES FOR THE USE OF THEIR REGULATORY ACTIONS IN PHYSIOLOGICAL CONCENTRATIONS

Volume 1, Issue 1, October 2016    |    PP. 1-7    |PDF (129 K)|    Pub. Date: November 2, 2016
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Author(s)
Karavay A., Department of Oncology of Grodno State Medical University, 80 Gorkogo str., 230015 Grodno, Belarus; Department of Biochemistry of Grodno State University, Grodno, Belarus 22, Ozeshko str., Grodno, 230023
Karavay P., Department of Oncology of Grodno State Medical University, 80 Gorkogo str., 230015 Grodno, Belarus; Department of Biochemistry of Grodno State University, Grodno, Belarus 22, Ozeshko str., Grodno, 230023
Kaliada T., Department of Oncology of Grodno State Medical University, 80 Gorkogo str., 230015 Grodno, Belarus; Department of Biochemistry of Grodno State University, Grodno, Belarus 22, Ozeshko str., Grodno, 230023
Nefyodov L., Department of Oncology of Grodno State Medical University, 80 Gorkogo str., 230015 Grodno, Belarus; Department of Biochemistry of Grodno State University, Grodno, Belarus 22, Ozeshko str., Grodno, 230023

Abstract
On the basis of experimental data we suggest that discovered differences in certain amino acids concentrations in blood plasma, red blood cells and tumors are criteria in early diagnostic of primary cancerous growth as well as in estimation of effectiveness specific cancer treatment. In clinical studies (1495 of patients with cancer of mammary gland, lungs, prostate, ovaries, bladder or digestive tract) we shown that in biological fluids and tumors of cancer patients significant changes of physiological concentrations of amino acids real or indirectly regulate processes of the antitumor response, oncogenesis, immunogenesis and apoptosis. Our strategy of application of amino acids as medicinal preparations includes a directional effect on the functional and metabolic relationships, which change in specific pathology through the effect on the regulatory mechanisms of intermediate metabolic reactions, limiting stages of metabolic flows, utilization of energy substrates and transport systems restricting the processes of amino acids pool formation. The creation methodology of pathogenetic compositions of amino acids and their derivatives on the basis of their physiological concentration for practical application in oncology of their regulatory effects discussed.

Keywords
Free amino acids; Regulatory effects; Oncology

Cite this paper
Karavay A., Karavay P., Kaliada T., Nefyodov L., METABOLIC COMFORT IN ONCOLOGY AND FREE AMINO ACIDS: PERSPECTIVES FOR THE USE OF THEIR REGULATORY ACTIONS IN PHYSIOLOGICAL CONCENTRATIONS, SCIREA Journal of Pharmacy. Vol. 1 , No. 1 , 2016 , pp. 1 - 7 .

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