Volume 1, Number 2 (2016)
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Home > Journals > SCIREA Journal of Clinical Medicine > Archive > Paper Information

Aqueous leaf extracts of Albizia lebbeck induce histological changes of reproductive organs of alloxan induced diabetic albino rats.

Volume 1, Issue 2, December 2016    |    PP. 336-353    |PDF (1734 K)|    Pub. Date: January 16, 2017
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Odey Daisy Mary, Department of Medical Laboratory Services University of Abuja Teaching Hospital PMB 228 Gwagwalada FCT Abuja, Nigeria.
Amos Dangana, Department of Medical Laboratory Services University of Abuja Teaching Hospital PMB 228 Gwagwalada FCT Abuja, Nigeria.
Idris Abdullah Nasir, Department of Medical Laboratory Services University of Abuja Teaching Hospital PMB 228 Gwagwalada FCT Abuja, Nigeria.
James Adisa, Department of Medical Laboratory Science Faculty of Medical Science, University of Jos

AbstractBackground: The frequent use of herbal preparations for treatment of infections and diseases have led to the need to investigate possible side effects that could be associated with these plants. Objective of study: This study was designed to investigate the effects of aqueous leaf extracts of Albizzia lebbeck on the histology of the male and female reproductive organs of alloxan induced diabetic Albino rats.Materials and methods:The rats (n = 40), weighing 100 – 150g were randomly assigned into five treatments groups (A-E). The rats were induced with diabetes using Alloxan (100mg/kg) administered interperitoneally (Groups B, C, D). Treatment groups were treated with distilled water (Group A), and aqueous leaf extract of Albizzia lebbeck (100mg to group C and E, 200mg to group D) administered orally via orogastric tubes. Results: All the rats were fed with pellets and clean water ad libitum. Cage side examination was done daily to observe for behavioral signs. It was observed that Albizzia lebbeck leaf extract in female rats had no effect on the histology of the uterine endometrium, but, the ovaries were found to have a decreasing number of follicles indicating a possible arrest of oogenesis. The male rat’s testes showed a parallel decrease in germinal epithelium in all groups from group A to group E indicating a decrease in spermatogenesis. It was also noted that Albizzia lebbeck caused a decrease in feed intake and animal weight in all treatment groups during the course of this study. Conclusion:Findings from The aqueous extract of A. lebbeck leaves causes spermatogenic and oogenic arrest in male and female albino rats respectively. However, Albizzia lebbeck should be subjected tofurther analysis in order to unravel the active ingredients responsible for their antifertility actions.

Antifertility; Albizzia lebbeck; Histology

Cite this paper
Odey Daisy Mary, Amos Dangana, Idris Abdullah Nasir, James Adisa, Aqueous leaf extracts of Albizia lebbeck induce histological changes of reproductive organs of alloxan induced diabetic albino rats., SCIREA Journal of Clinical Medicine. Vol. 1 , No. 2 , 2016 , pp. 336 - 353 .


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