Prevalence, patterns and management of diabetic dyslipidemia among black South African patients with type 2 diabetes at a South African semi-urban tertiary Hospital

Volume 5, Issue 6, December 2020     |     PP. 144-159      |     PDF (270 K)    |     Pub. Date: December 1, 2020
DOI:    199 Downloads     3317 Views  

Author(s)

P.T. Moshane, Department of Internal Medicine, Sefako Makgatho Health Sciences University, Pretoria, South Africa.
M.A. Mogale, Department of Biochemistry, Sefako Makgatho Health Sciences University, Pretoria, South Africa.
A. Adu, Department of Internal Medicine, Sefako Makgatho Health Sciences University, Pretoria, South Africa.
O.A. Towobola, Department of Internal Medicine, Sefako Makgatho Health Sciences University, Pretoria, South Africa.

Abstract
Background: Despite widespread availability and use of statin lipid lowering drugs in the management of diabetic dyslipidaemia (DD), many patients with Type-2 diabetes mellitus (T2DM) do not reach the lipid targets recommended by most diabetic management guidelines. This study, highlights the prevalence and patterns of DD among black South African patients with T2DM, and assesses the management of DD at Dr George Mukhari Academic Hospital (DGMAH). Methods: Two hundred and three medical records of black South African patients with T2DM were reviewed retrospectively. The last three lipid profile results were recorded and analysed for the presence of DD as well as for the patterns of DD. In addition, information regarding how physicians at DGMAH manage DD was recorded and analysed.Results: The study subjects were predominantly males (58.5%) and the prevalence of DD among the subjects was 56.3%. The patterns of dyslipidaemia observed in the study were mixed dyslipidaemia (7.1%), combined dyslipidaemia (25.7) and single isolated dyslipidaemia (23.5%). The most common types of combined dyslipidaemia were elevated total cholesterol (TC) + elevated low density lipoprotein (LDL) (10.9%) and reduced high density lipoprotein (HDL) + elevated triglycerides (TG) (9.8%) whereas the most common single dyslipidaemia was reduced HDL (15.3%). With regards to the management of DD at DGMAH, the study revealed that physicians at this hospital do not manage DD in accordance with recommendations of most DD treatment guidelines.Conclusion: The prevalence of DD at DGMAH is lower than those previously reported in the literature. The most common patterns of DD at this hospital are the combined (↓[HDL], & ↑[TG] and single isolated reduced HDL. Also, the management of DD at this hospital is not in line with recommendations by treatment guidelines.

Keywords
Diabetic dyslipidaemia, prevalence, patterns, management, South Africans.

Cite this paper
P.T. Moshane, M.A. Mogale, A. Adu, O.A. Towobola, Prevalence, patterns and management of diabetic dyslipidemia among black South African patients with type 2 diabetes at a South African semi-urban tertiary Hospital , SCIREA Journal of Clinical Medicine. Volume 5, Issue 6, December 2020 | PP. 144-159.

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