Bone Loss in Black South African women: Transition from Perimenopause to Menopause

Volume 5, Issue 6, December 2020     |     PP. 160-172      |     PDF (901 K)    |     Pub. Date: December 1, 2020
DOI:    196 Downloads     3447 Views  

Author(s)

Lineo Matsela, Department of Obstetrics & Gynaecology, School of Medicine, Sefako Makgatho Health Sciences University, Pretoria, South Africa
Olakunle A. Towobola, Department of Internal Medicine, School of Medicine, Sefako Makgatho Health Sciences University, Pretoria, South Africa
Ephraim T. Mokgokong, Department of Obstetrics & Gynaecology, School of Medicine, Sefako Makgatho Health Sciences University, Pretoria, South Africa

Abstract
ABSTRACT Objective: Loss of bone mineral density follows as a consequence of hormonal changes, as women transit from perimenopause to menopause. This study investigated the effect of such a transition on bone demineralisation among Black South African women.Methods: Two groups of women stratified by their menstrual history into perimenopause (n = 28) and postmenopause (n = 32), were enrolled for the study. Each of the study participants had her Body Mass Index (BMI) determined and a sample of blood was taken and analysed for follicle stimulating hormone (FSH). Bone mineral density was assessed for the hip bone using the Dual-Energy X-ray Absorptiometry machine (DEXA; Hologic 4500). Results: The mean age (± SD) of perimenopausal women was 44.6 years (± 3.6) compared with 63.4 years (± 7.2) for postmenopausal women. There was no statistical significant difference in the BMI of women in the two groups (p = 0.4671) and the serum FSH concentration of 46 to 100 mIu/mL (mean = 78 mIu/Ml; ± 0.69) confirmed the status of postmenopause. The negative slope of the change in hip BMD amongst perimenopausal women (-0.0006) translates to BMD loss of 0.06% per annum. This compares with hip BMD loss of -0.0025 (i.e. BMD loss of 0.25%/annum) amongst the postmenopausal women. This represents a 4-fold loss of BMD in postmenopausal compared with perimenopausal women.Conclusions: This study provides evidence that black South African women would begin to experience loss of bone mineral density of the hip in their transition from perimenopause to postmenopausal state. Key words: Bone Mineral Density; perimenopause; postmenopause, Dual Energy Absorptiometry

Keywords
Key words: Bone Mineral Density; perimenopause; postmenopause, Dual Energy Absorptiometry

Cite this paper
Lineo Matsela, Olakunle A. Towobola, Ephraim T. Mokgokong, Bone Loss in Black South African women: Transition from Perimenopause to Menopause , SCIREA Journal of Clinical Medicine. Volume 5, Issue 6, December 2020 | PP. 160-172.

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