Clinical evaluation of Radio Frequancy Ablation(RFA)in the treatment of Gestational trophoblastic tumor(GTT)

Volume 5, Issue 6, December 2020     |     PP. 173-182      |     PDF (231 K)    |     Pub. Date: December 3, 2020
DOI:    211 Downloads     3422 Views  

Author(s)

Shaadaiti·Wufuer, Department of Gynecology, The First Affiliated Hospital of Xinjiang, Medical University,Department of Gynecology,The International Hospital of Urumqi,Urumqi830054, Xinjiang,China
Anaguli·Ababaikeli, Department of Gynecology, The First Affiliated Hospital of Xinjiang, Medical University,Department of Gynecology,The International Hospital of Urumqi,Urumqi830054, Xinjiang,China
Gulina·Ababaikeli, Department of Gynecology, first Affiliated Hospital of Xinjiang Medical University,830054,No.393 Xin Yi road,Urumqi, Xinjiang, People’s Republic of China

Abstract
Objective: To discuss the feasibility and therapeutic efficacy of the three types of treatment methods for Gestational trophoblastic tumor(GTT).
Methods: 72 patients diagnosed as GTT were selected and divided into three groups according to different treatment styles including single chemotherapy (group A), Total hysterectomy combined with chemotherapy (group B), and Radio Frequancy Ablation (RFA) combined with chemotherapy (group C) .The curative effects of three groups were evaluated according to the blood HCG levels and remission of metastasis. Result: The curative effect rates of the three groups from A to C were respectively 93.3%, 93.3%,100% . there was no significant differences between three groups (P>0.05). the remission rate of GTT has statistical significance at different stages (P<0.05), but the differences has no statistical significance among the groups of different ages,and different types. the course frequency of chemotherapy in group A and B was significantly shorter than group C ( p<0.05).
Conclusion: GTT is mainly treated by chemotherapy. Patients suffering from GTT can get satisfactory treatment by Total hysterectomy or RFA combined with chemotherapy. RFA combined with chemotherapy is the best choice for the younger patients who has fertility requirements

Keywords
Gestational Trophoblastic Tumor; Treatment; Radio Frequency Ablation (RFA)

Cite this paper
Shaadaiti·Wufuer, Anaguli·Ababaikeli, Gulina·Ababaikeli, Clinical evaluation of Radio Frequancy Ablation(RFA)in the treatment of Gestational trophoblastic tumor(GTT) , SCIREA Journal of Clinical Medicine. Volume 5, Issue 6, December 2020 | PP. 173-182.

References

[ 1 ] Yang X, Meiying Q. The quality of life of gestational throphoblastic tumors.Chinese Journal of Obstetrics and Gynecology, 2010,(1):71-72.
[ 2 ] Xiang Y, Hong zh S. Trophoblastic Oncology. T0he third edition.Beijing:People’s Medical Publishing House,2011:301.
[ 3 ] Wang J, Short D, Sebire NJ, et al. Salvage chemotherapy of re-with paclitaxel/cisplatin alternating with paclitaxel/etoposide lapsed or high-risk gestational trophoblastic neoplasia(GNT)(TP/TE). Ann Oncol, 2008,19(9):1578-1583.
[ 4 ] Feng F, Xiang Y, Li L, et al. Clinical parameters predicting thera-peutic response to surgical management in patients with chemotherapy-resistant gestational trophoblastic neoplasia. Gynecol Oncol, 2009, 133(3):312-315.
[ 5 ] Carter J,Chi DS, Brown CL, et al. Cancer-related infertility insurvivorship. Lilt J Gynecol Cancer, 2010,20(1):2-8.
[ 6 ] Shaadaiti·Wufuer,Zainuer·abudureyimu, Gulina·Ababaikeli. The clinical analysis on ultrasound-guided radiofrequency ablation for 29 cases of adenomyosis. the Journal Practical Obstetrics and Gynecology,2013,29(6):469-470.
[ 7 ] Cagayan MS, Magallances MS. The role of adjuvant surgery in the management of gestational trophoblastic neoplasia. J Reported Med, 2008,(7):513-518.
[ 8 ] Jiang TF, Yalin Zh, Hong X,ect. The effect of assisted hysterectomy on gestational trophoblastic tumor. the Journal Practical Obstetrics and Gynecology, 2011,27(10):784-786.
[ 9 ] Xin X. Obstetrics and Gynecology. The eighth edition.Beijing: People’s Medical Publishing House. 2014:342.
[ 10 ] Ngan S, Seck MJ. Gestational trophoblastic neophasia management: An updme. Curt Opin Oncol, 2007,19(5):486-491.
[ 11 ] Lurain JR. Gestational trophoblastic disease II: classifcation and management of gestational trophoblastic neoplasia. Am J Obstet Gynecol, 2011,204(1):11-18.
[ 12 ] Weiguo Lv. The diagnosis and treatment of recurrent and drug resistant gestational trophoblastic tumor[J]. Chinese Journal of Practical Gynecology and Obstetrics, 2015,(3):220-223.
[ 13 ] Jun Zhao, Yang Xiang. The prognosis assessment and follow-up of drug resistant gestational trophoblastic tumor, Chinese Journal of Practical Gynecology and Obstetrics, 2015,(3):223-226.
[ 14 ] Iversen H, Lenz S, Dueholm. Ultrasound-guided radiofrequency ablation of symptomatic uterine fibroids: short-term evaluation of effect of treatment on quality of life and symptom severity. Ultasound Obstet Gynecol, 2012,40(4):445-451.
[ 15 ] Venkatesan AM, Partanen A, Pulanic TK, et al. Magnetic resonance imaging-guided volumetric ablation of symptomatic leiomyomatal correlation of imaging with histology. J Vasc Interv Radiol, 2012,23(6):786-794.
[ 16 ] Jing Lu, Yuka Yuan. The clinical application of radiofrequnce ablation on uterine myoma. Internationa Journal of Obstetrics and Gynecology, 2014,41(3):256-259.