Syncope in Chronic Constitutional Hypotension: Gender based Retrospective observational study in symptomatic women

Volume 1, Issue 1, October 2016     |     PP. 38-48      |     PDF (316 K)    |     Pub. Date: October 14, 2016
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Alfonso Lagi MD. PhD, Internal Medicine Unit Villa Donatello Hospital - Firenze
Simone Cencetti MD, Ospedale Santa Maria Nuova Syncope Unit – Firenze

Introduction: the association between chronic constitutional hypotension (CCH) and symptoms is uncertain both as pathophysiological correlation as a statistical link. The study was undertaken in order to investigate the existence of a significant association between CCH and symptoms and identify the most represented ones.Methods: females only have been used because of the higher incidence of CCH in their sex. The symptoms considered were studied in three groups of subjects: A and B groups, identified for systolic arterial pressure (SAP) <100 mmHg and diastolic blood pressure (DAP) <60 mmH, and finally a C group of control consisting of normotensive women. Symptoms considered were: dizziness, anxiety / or depression, asthenia and / or fatigue, transient loss of consciousness (TLC), accidental falls, and body mass index (BMI).Results: patients with CCH had significant incidence of anxiety / depression and asthenia / fatigue and TLC versus controls. Individuals with PAD <60 mmHg (group B) had a significance statistical difference of events also vs. the group A.Discussion and conclusion: the females with CCH are symptomatic and have a lower BMI than controls. The low value of PAD defines a major risk group for TLC and a worse prognosis.

Gender based Retrospective observational study in symptomatic women

Cite this paper
Alfonso Lagi MD. PhD, Simone Cencetti MD, Syncope in Chronic Constitutional Hypotension: Gender based Retrospective observational study in symptomatic women , SCIREA Journal of Clinical Medicine. Volume 1, Issue 1, October 2016 | PP. 38-48.


[ 1 ] Pemberton J. Does constitutional hypotension exist? BMJ 1989; 298: 660–662.
[ 2 ] Owens PE, Lyons SP, O’Brien ET. Arterial hypotension: prevalence of low blood pressure in the general population using ambulatory blood pressure monitoring, Journal of Human Hypertension 2000; 14: 243–247
[ 3 ] Kochar MS. Chaptcr 18 In: Hunyor S, ed. Hvpotension in cardiovascular drug therapy. Sydney: Williatms & W'illiams ADIS, 1987:149-57
[ 4 ] Braunwald E, cd. Harrison's principles of internal medicine. I I th ed. New York: McGraw-Hill, 1987
[ 5 ] National Institute of' Occupational Health and Safety Blood Pressure Study Handbook of tables. Canberra: Australian Government Publishing Service,1987
[ 6 ] Broadbent RE, Cooper PF, FitzGerald P, Parkes KR. The cognitive failure questionnarie (CFQ) and its correlates. Br. J. Clin. Psycol. 1982;21:1-16
[ 7 ] Grosch S, Maillet J, Krzesinski JM. Attitude à adopter devant une pression artérielle chroniquement basse. Rev Med Liege 2006; 61(5-6) : 374-379
[ 8 ] Wessely S, Nickson J, Cox B. Symptoms of low blood pressure: a population study Br Med J 1990;301:362-365