Post Viral Fatigue Syndrome effectively treated with Hyperbaric Oxygen Therapy.

Volume 7, Issue 1, February 2022     |     PP. 1-15      |     PDF (364 K)    |     Pub. Date: January 5, 2022
DOI: 10.54647/cm32515    83 Downloads     5126 Views  


Emily L. Perreault, ARNP, MSN Progressive Rehabilitation Medicine, Cedar Rapids, Iowa 52402
Francesca Arese Lucini, Phd Lead Researcher at WAVi Co. 3535 So Irving St. Englewood, CO 80101
Sunny Kim, MD Progressive Rehabilitation Medicine, Cedar Rapids, Iowa 52402

In this case study we will present the case of a 27-year-old patient that requested Hyperbaric Oxygen treatment (HBOT) to improve his cognitive performance. After a couple of years of poor general wellbeing, brain fog and fatigue the patient underwent approximately 20 hours of HBOT at the end of which he reported a significant improvement in his mental performance, vitality and social functioning. The effect of HBOT therapy has been validated through EEG test and retest scans that show an overall improvement of both the P300 measures and the EEG spectrum analysis. Subjective data on his perceived health was obtained by SF-36 pre and post treatment which revealed significant improvements in the majority of the markers. These changes of qEEG metrics and quality of life measures suggest that HBOT could be an effective treatment for general cognitive impairment, and we therefore suggest further research should be warranted and more data collected.

HBOT, hyperbaric oxygen, EEG spectrum analysis, SF-36, cognitive impairment

Cite this paper
Emily L. Perreault, Francesca Arese Lucini, Sunny Kim, Post Viral Fatigue Syndrome effectively treated with Hyperbaric Oxygen Therapy. , SCIREA Journal of Clinical Medicine. Volume 7, Issue 1, February 2022 | PP. 1-15. 10.54647/cm32515


[ 1 ] Arns, Martijn, Wilhelmus Drinkenburg, and J. Leon Kenemans. "The effects of QEEG-informed neurofeedback in ADHD: an open-label pilot study." Applied psychophysiology and biofeedback 37.3 (2012): 171-180.
[ 2 ] Boussi-Gross, R., Golan, H., Fishlev, G., Bechor, Y., Volkov, O., Bergan, J., . . . Efrati, S. (2013). Hyperbaric Oxygen Therapy Can Improve Post-Concussion Syndrome Years after Mild Traumatic Brain Injury - Randomized Prospective Trial. PLoS ONE, 8(11). doi:10.1371/journal.pone.0079995
[ 3 ] Buckley CJ, Cooper JS. Hyperbaric, Angiogenesis. [Updated 2020 Aug 16]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan-. Available from:
[ 4 ] Chandra, C., Bhateja, D., Bhateja, D. K., & Chandra, S. (2010). The Healing effect of hyperbaric oxygen therapy- a review. Indian Journal of Public Health Research and Development, 1(2), 30-33. Retrieved September 29, 2020.
[ 5 ] Chaturvedi, Menorca, et al. "Quantitative EEG (QEEG) measures differentiate Parkinson's disease (PD) patients from healthy controls (HC)." Frontiers in aging neuroscience 9 (2017): 3. APA
[ 6 ] Centers for Disease Control. Epstein-barr. (2020, February 26). Retrieved December 03, 2020, from
[ 7 ] Clayton, Gerald, et al. "In-clinic event related potentials after sports concussion: A 4-year study." Journal of pediatric rehabilitation medicine Preprint (2020): 1-12.
[ 8 ] Ezra N, Dang K, Heuser G. Improvement of attention span and reaction time with hyperbaric oxygen treatment in patients with toxic injury due to mold exposure. European Journal of Clinical Microbiology & Infectious Diseases: Official Publication of the European Society of Clinical Microbiology. 2011 Jan;30(1):1-6. DOI: 10.1007/s10096-010-0937-8.
[ 9 ] Ferreri, Florinda, et al. "Age related differences in functional synchronization of EEG activity as evaluated by means of TMS-EEG coregistrations." Neuroscience letters 647 (2017): 141-146.
[ 10 ] Gonzales-Portillo, B., Lippert, T., Nguyen, H., Lee, J., & Borlongan, C. (2019). Hyperbaric oxygen therapy: A new look on treating stroke and traumatic brain injury. Brain Circulation, 5(3), 101. doi:10.4103/bc.bc_31_19
[ 11 ] Gordeev, S. A. (2007). The use of endogenous P300 Event-related potentials of the brain for assessing cognitive functions in healthy subjects and in clinical practice. Human Physiology, 33(2). Doi:10.1134/S0362119707020168
[ 12 ] Harch P. G. (2015). Hyperbaric oxygen in chronic traumatic brain injury: oxygen, pressure, and gene therapy. Medical gas research, 5, 9.
[ 13 ] Harch, P., Andrews, S., Rowe, C., Lischka, J., Townsend, M., Yu, Q., & Mercante, D. (2020). Hyperbaric oxygen therapy for mild traumatic brain injury persistent postconcussion syndrome: A randomized controlled trial. Medical Gas Research, 10(1), 8. doi:10.4103/2045-9912.279978
[ 14 ] Hayes, Jasmeet P., Bigler, Erin D., and Verfaellie, Mieke. "Traumatic brain injury as a disorder of brain connectivity." Journal of the International Neuropsychological Society 22.2 (2016): 120-137.
[ 15 ] Hunter, Aimee M., et al. "Antidepressant response trajectories and quantitative electroencephalography (QEEG) biomarkers in major depressive disorder." Journal of psychiatric research 44.2 (2010): 90-98.
[ 16 ] Kappenman ES, Luck SJ. The Effects of Electrode Impedance on Data Quality and Statistical Significance in ERP Recordings. Psychophysiology. 2010: 47(5): 888-904
[ 17 ] Klassen, B. T., et al. "Quantitative EEG as a predictive biomarker for Parkinson disease dementia." Neurology 77.2 (2011): 118-124.
[ 18 ] Lam, G., Fontaine, R., Ross, F. L., & Chiu, E. S. (2017). Hyperbaric Oxygen Therapy. Advances in Skin & Wound Care, 30(4), 181-190. doi:10.1097/01.asw.0000513089.75457.22
[ 19 ] Liu, B., Zhang, Y. H., Jiang, Y., Li, L. L., Chen, Q., He, G. Q., Tan, X. D., & Li, C. Q. (2015). Gadd45b is a novel mediator of neuronal apoptosis in ischemic stroke. International journal of biological sciences, 11(3), 353–360.
[ 20 ] Logsdon, Aric F., et al. "Role of microvascular disruption in brain damage from traumatic brain injury." Comprehensive Physiology5.3 (2011): 1147-1160.
[ 21 ] Meng, X. E., Zhang, Y., Li, N., Fan, D. F., Yang, C., Li, H., Guo, D. Z., & Pan, S. Y. (2016). Hyperbaric Oxygen Alleviates Secondary Brain Injury After Trauma Through Inhibition of TLR4/NF-κB Signaling Pathway. Medical science monitor: international medical journal of experimental and clinical research, 22, 284–288.
[ 22 ] Ogrim, Geir, Juri Kropotov, and Knut Hestad. "The QEEG theta/beta ratio in ADHD and normal controls: sensitivity, specificity, and behavioral correlates." Psychiatry Research198.3 (2012): 482-488.
[ 23 ] Readnower, R. D., Chavko, M., Adeeb, S., Conroy, M. D., Pauly, J. R., McCarron, R. M., & Sullivan, P. G. (2010). Increase in blood-brain barrier permeability, oxidative stress, and activated microglia in a rat model of blast-induced traumatic brain injury. Journal of neuroscience research, 88(16), 3530–3539.
[ 24 ] Richards, T. L., et al. "Double-blind study of pulsing magnetic field effects on multiple sclerosis." The Journal of Alternative and Complementary Medicine 3.1 (1997): 21-29.
[ 25 ] Shojo, H., Borlongan, C. V., & Mabuchi, T. (2017). Genetic and Histological Alterations Reveal Key Role of Prostaglandin Synthase and Cyclooxygenase 1 and 2 in Traumatic Brain Injury-Induced Neuroinflammation in the Cerebral Cortex of Rats Exposed to Moderate Fluid Percussion Injury. Cell transplantation, 26(7), 1301–1313.
[ 26 ] Stępień, K., Ostrowski, R. P., & Matyja, E. (2016). Hyperbaric oxygen as an adjunctive therapy in treatment of malignancies, including brain tumours. Medical Oncology, 33(9). doi:10.1007/s12032-016-0814-0
[ 27 ] Tal, S., Hadanny, A., Berkovitz, N., Sasson, E., Ben-Jacob, E., & Efrati, S. (2015). Hyperbaric oxygen may induce angiogenesis in patients suffering from prolonged post-concussion syndrome due to traumatic brain injury. Restorative Neurology and Neuroscience, 33(6), 943-951. doi:10.3233/rnn-150585
[ 28 ] Thom, S. R., Bhopale, V. M., Velazquez, O. C., Goldstein, L. J., Thom, L. H., & Buerk, D. G. (2006). Stem cell mobilization by hyperbaric oxygen. American Journal of Physiology-Heart and Circulatory Physiology, 290(4). doi:10.1152/ajpheart.00888.2005
[ 29 ] Vazquez-Marrufo, Manuel, et al. "Quantitative electroencephalography reveals different physiological profiles between benign and remitting-relapsing multiple sclerosis patients." Bmc Neurology 8.1 (2008): 44.
[ 30 ] Ware J, Kosinski M, Bjorner J, Turner-Bowker D, Gandek B, Maruish M. Development. User's Manual for the SF-36v2® Health Survey. Lincoln (RI): Quality Metric Incorporated. (2007): 3-12.