Antioxidants and bioactivities of total flavonoids Extracted from Kunlun Chrysanthemum Flowers

Volume 3, Issue 3, June 2018     |     PP. 25-49      |     PDF (1272 K)    |     Pub. Date: September 25, 2018
DOI:    1555 Downloads     7564 Views  

Author(s)

Hongyue Zhai, College of Life Sciences and Technology, Xinjiang University, Shengli Road 14, Urumqi, Xinjiang 830046, China
Siqun Jing, College of food science and Engineering, Shaoguan University, Daxue Road 288, Shaoguan, Guangdong 512005, China
Leping Su, College of Life Sciences and Technology, Xinjiang University, Shengli Road 14, Urumqi, Xinjiang 830046, China
Zhiyan Ren, College of Life Sciences and Technology, Xinjiang University, Shengli Road 14, Urumqi, Xinjiang 830046, China
Yinna Wang, College of Life Sciences and Technology, Xinjiang University, Shengli Road 14, Urumqi, Xinjiang 830046, China
Liang-Jun Yan, Department of Pharmaceutical Sciences, UNT System College of Pharmacy, University of North Texas Health Science Center, Fort Worth, TX 76107, United States

Abstract
Plant extracts have medicinal and pharmacological values. The aim of the present study was to evaluate the antioxidant activity, antibacterial property, and protective effect on liver injury induced by carbon tetrachloride (CCl4) in mice as well as the antiproliferative effect on tumor cells of Kunlun Chrysanthemum total flavonoids (KCTF). We measured free radical scavenging activities of KCTF and also evaluated KCTF's antioxidative effects on lipid peroxidation and superoxide dismutase activity. Moreover, KCTF's detoxification effect was assessed on acute liver injury in mouse induced by carbon tetrachloride (CCl4) and its anti-proliferation property was determined using HeLa cells and esophageal cancer cells. Results indicated that KCTF had significant antioxidant activity. KCTF inhibited the growth of both Gram positive and Gram negative bacteria. However, KCTF had no significant protective effect on acute liver injury induced by CCl4. Results of the antiproliferative effect of KCTF on HeLa cells and Eca109 cells indicated that KCTF possessed great inhibitory activity with average IC50 values of 133.6±0.1885 μg/mL, 192.0±0.07719 μg/mL, respectively. Therefore, the present study indicates that KCTF may have potential application on functional food industry due to its natural antioxidant, bacteriostatic and antiproliferative effects.

Keywords
Kunlun Chrysanthemum total flavonoids (KCTF); antioxidant activity; antibacterial property; antiproliferative effect; liver injury

Cite this paper
Hongyue Zhai, Siqun Jing, Leping Su, Zhiyan Ren, Yinna Wang, Liang-Jun Yan, Antioxidants and bioactivities of total flavonoids Extracted from Kunlun Chrysanthemum Flowers , SCIREA Journal of Chemistry. Volume 3, Issue 3, June 2018 | PP. 25-49.

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