Research Progress on miR-143 and miR-145 in Esophageal Cancer

Volume 7, Issue 6, December 2022     |     PP. 361-375      |     PDF (279 K)    |     Pub. Date: December 11, 2022
DOI: 10.54647/cm32969    92 Downloads     3047 Views  


Minggang Du, Clinical Medical College, Jiamusi University, China

Esophageal cancer is one of the malignancies that with high occurrence in China. Its high morbidity and mortality have caused huge disease burden for the society. Therefore, it is getting necessary to elucidate the molecular mechanisms regarding the onset and progression of esophageal cancer. Increasing studies suggest that miR-143 and miR-145 are differentially expressed and deeply involved in the progression, chemotherapy resistance, radiotherapy resistance and other processes in esophageal cancer. The two miRNAs also associate with the prognosis of patients with esophageal cancer. Discussing the roles of miR-143 and miR-145 in esophageal cancer may further contribute to ascertain their relevant molecular mechanisms and clarify the value of the two miRNAs as potential biomarkers and molecular targets, in an attempt to provide new insights for the clinical treatment of esophageal cancer.

miR-143, miR-145, esophageal cancer, ERK signaling pathway, p38 signaling pathway, JAK/STAT signaling pathway, PI3K/AKT signaling pathway, Wnt signaling pathway

Cite this paper
Minggang Du, Research Progress on miR-143 and miR-145 in Esophageal Cancer , SCIREA Journal of Clinical Medicine. Volume 7, Issue 6, December 2022 | PP. 361-375. 10.54647/cm32969


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