Etiology of short stature in children and adolescents

Volume 1, Issue 1, October 2016     |     PP. 75-85      |     PDF (174 K)    |     Pub. Date: October 15, 2016
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Kobra Shiasi Arani, Research Center for Biochemistry and Nutrition in metabolic diseases, Kashan University of Medical Sciences, Kashan, I.R. Iran
Sedighe Asgarian, Research Center for Biochemistry and Nutrition in metabolic diseases, Kashan University of Medical Sciences, Kashan, I.R. Iran

Introduction:Short stature is one of the most common causes of referral to the endocrinology and pediatric clinics and in most cases is due to normal variants of growth such as familial short stature or constitutional growth delay, but it may be due to some treatable and important diseases. In this study we investigate the causes of short stature in children and adolescents. Material and Method: Every child or adolescent under 18 years old with height below 3rd percentile of growth charts, referred pediatric endocrinology clinic, included to the study. The height and weight of the children and their parents were measured and physical examination was done in order to find the cause of short stature. For all children a set of routine lab data performed. The left hand x-ray of each child was taken to determine the bone age and for evidences of bone dysplasia. Growth hormone stimulation test applied if there was any indication for this test.Result: A total of 363 child and adolescent (173 male, 190 female) with short stature were studied. The more common causes of short stature included: familial short stature 39.9% (112 person), constitutional growth delay 26.4% (96 person), growth hormone deficiency 9.1% (34 person). The less common causes of short stature included: hypopitutarism , hypothyroidism , achondroplasia ,hypochondroplasia, Addison disease, cancer, chronic hepatitis, congenital ichtiosis, cystic fibrosis, cystinosis, Down syndrome and etc. Conclusion: The most common cause of short stature in both sex was a normal variance followed by growth hormone deficiency. Less common but treatable causes should be always in differential diagnosis.

Short stature, Growth, Constitutional growth delay, Familial Short stature, Children

Cite this paper
Kobra Shiasi Arani, Sedighe Asgarian, Etiology of short stature in children and adolescents , SCIREA Journal of Clinical Medicine. Volume 1, Issue 1, October 2016 | PP. 75-85.


[ 1 ] Allen, D.B. and L. Cuttler, Clinical practice. Short stature in childhood--challenges and choices. N Engl J Med, 2013. 368(13): p. 1220-8.
[ 2 ] Halac, I. and D. Zimmerman, Evaluating short stature in children. Pediatr Ann, 2004. 33(3): p. 170-6.
[ 3 ] Carrascosa, A., et al., [Idiopathic short stature. A literature review and update]. An Pediatr (Barc), 2011. 75(3): p. 204 e1-11.
[ 4 ] Pedicelli, S., et al., Controversies in the definition and treatment of idiopathic short stature (ISS). J Clin Res Pediatr Endocrinol, 2009. 1(3): p. 105-15.
[ 5 ] Rosenbloom, A.L., Idiopathic short stature: conundrums of definition and treatment. Int J Pediatr Endocrinol, 2009. 2009: p. 470378.
[ 6 ] Majcher, A., J. Bielecka-Jasiocha, and B. Pyrzak, [Analysis of reasons of short stature in own material]. Pediatr Endocrinol Diabetes Metab, 2009. 15(3): p. 152-6.
[ 7 ] Lee, J.M., et al., Short stature in a population-based cohort: social, emotional, and behavioral functioning. Pediatrics, 2009. 124(3): p. 903-10.
[ 8 ] Kossiva, L., et al., Too short stature, too many stigmata. BMJ Case Rep, 2010. 2010.
[ 9 ] Albertsson-Wikland, K., et al., Dose-dependent effect of growth hormone on final height in children with short stature without growth hormone deficiency. J Clin Endocrinol Metab, 2008. 93(11): p. 4342-50.
[ 10 ] Soriano-Guillen, L. and J. Argente, [Idiopathic short stature and treatment with biosynthetic growth hormone: clinical and ethical reflections on an arbitrary diagnosis]. An Pediatr (Barc), 2012. 76(2): p. 53-7.
[ 11 ] Hughes, I.P., et al., Growth hormone regimens in Australia: Analysis of the first 3 years of treatment for idiopathic growth hormone deficiency and idiopathic short stature. Clin Endocrinol (Oxf), 2012. 77(1): p. 62-71.
[ 12 ] Chowdhury sp, S.T., Haldar D,Taraphdar P,Nakar TK, Sarkar GN, Short stature in children :experience from a tertiary care hospital in Kolkta, India. The Health 2011. 2(4): p. 139-142.
[ 13 ] alaei MR , R.A., Rezaie M , Nourbakhsh MK Etiological profile of short stature in a referral endocrinology clinic Iranian Journal of Pediatrics, 2007. 17(Suppl.1): p. 61-66.
[ 14 ] Oostdijk, W., et al., Diagnostic approach in children with short stature. Horm Res, 2009. 72(4): p. 206-17.
[ 15 ] Kaplowitz, P. and J. Webb, Diagnostic evaluation of short children with height 3 SD or more below the mean. Clin Pediatr (Phila), 1994. 33(9): p. 530-5.
[ 16 ] Siamak Shiva, A.N., Etiology of Short Stature in East Azerbaijan, Iran Iranian Journal of Pediatrics 2009. 19(1): p. 35-40.
[ 17 ] El Mouzan, M.I., et al., Regional prevalence of short stature in Saudi school-age children and adolescents. ScientificWorldJournal, 2012. 2012: p. 505709.
[ 18 ] Deodati, A. and S. Cianfarani, Impact of growth hormone therapy on adult height of children with idiopathic short stature: systematic review. BMJ (Clinical research ed.), 2011. 342.
[ 19 ] Sultan, M., et al., Etiology of short stature in children. J Coll Physicians Surg Pak, 2008. 18(8): p. 493-7.
[ 20 ] Assar Shideh , S.H., Riahi Kourosh,Kheradmand Keramat, Frequency of Growth Hormone Deficiency in Children with Short Stature Journal of Isfahan Medical School 2010. 28(104): p. 36-42.
[ 21 ] Mohammadian S, K.H., Nematollahi MR The causes of short stature among children in Gorgan-Iran Journal of Gorgan University of Medical Sciences, 2008. 10(3): p. 65-70.
[ 22 ] Soheili Khah S, H.A., Factors involved in short stature in 7-15 years patients in endocrine centers in Yazd Journal of Shahid Sadoughi University of Medical Sciences And Health Services, 2001. 9(3): p. 3-9.