Serum lipid profiling in decompensated patients with Hepatitis B virus -related cirrhosis

Volume 9, Issue 1, February 2024     |     PP. 361-369      |     PDF (211 K)    |     Pub. Date: October 7, 2023
DOI: 10.54647/cm321189    55 Downloads     867 Views  

Author(s)

Changzhi Xu, Department of Laboratory Medicine, Third Affiliated Hospital of Sun Yat-sen university, Guangzhou, Guangdong 510530, P.R.China
Yanhua Yi, Department of Emergency, Third Affiliated Hospital of Sun Yat-sen university, Guangzhou, Guangdong 510530, P.R.China
Zhizhi Xie, Department of Laboratory Medicine, Third Affiliated Hospital of Sun Yat-sen university, Guangzhou, Guangdong 510530, P.R.China
Donglin Zhu, Department of Laboratory Medicine, Third Affiliated Hospital of Sun Yat-sen university, Guangzhou, Guangdong 510530, P.R.China
Zhu Wang, Department of Urology, Affiliated Longhua People's Hospital, Southern Medical University, Shenzhen, Guangdong 510080, P.R.China
Yun Xi, Department of Laboratory Medicine, Third Affiliated Hospital of Sun Yat-sen university, Guangzhou, Guangdong 510530, P.R.China

Abstract
Background: The association of lipid profile with decompensation in patients with liver cirrhosis has not been clarified. The present study aimed to investigate the impact of Hepatitis B virus (HBV) infection on the lipid profile in decompensated patients with hepatitis B cirrhosis.
Methods: A total of 178 HBV-related decompensated cirrhosis (HBV-DeCi) patients were included in this retrospective analysis. The included patients were subdivided into 4 groups: 24 patients with HBsAg, HBeAg and HBcAb positive were set as group Ia; 14 patients with HBsAg, HBeAg ,HBeAb and HBcAb positive were set as group Ib;112 patients with HBsAg, HBeAb and HBcAb positive were set as group II; 28 patients with HBsAb, HBeAb and HBcAb positive were set as group III. Lipid profile included total cholesterol (TC), high-density lipoprotein-cholesterol (HDL-c), low-density lipoprotein- cholesterol (LDL-c), triglycerides (TG), and lipoprotein(a) (Lpa) were analyzed respectively. The difference between mentioned groups and the HBV infection were characterized respectively.
Results: Our data showed that the values of TG in group Ia was 1.2181 ± 0.1898 (mmol/L), in Ib was 1.306 ± 0.1702 (mmol/L), in Ia+Ib was 1.29 ± 0.1338 (mmol/L), and in group III was 0.8950±0.07200 (mmol/L). There were significant differences between group Ia and III (P=0.0498), Ib and III (P=0.0125) and also between group Ia+Ib and III (P=0.0217).
Conclusions: Serum TG levels are closely related to the HBV infection in HBV-DeCi patients. It may be used as a new indicator of advanced liver disease and cirrhosis recompensation.

Keywords
hepatitis B virus, decompensated cirrhosis, Lipid profile

Cite this paper
Changzhi Xu, Yanhua Yi, Zhizhi Xie, Donglin Zhu, Zhu Wang, Yun Xi, Serum lipid profiling in decompensated patients with Hepatitis B virus -related cirrhosis , SCIREA Journal of Clinical Medicine. Volume 9, Issue 1, February 2024 | PP. 361-369. 10.54647/cm321189

References

[ 1 ] Boemeke L, Bassani L, Marroni CA, et al. Lipid profile in cirrhotic patients and its relation to clinical outcome. Arq Bras Cir Dig. 2015;28(2):132–135. doi:10.1590/S0102-67202015000200012
[ 2 ] Jeon S, Carr R. Alcohol effects on hepatic lipid metabolism. J Lipid Res. 2020;61(4):470–479. doi:10.1194/jlr.R119000547
[ 3 ] Ruirui Feng, Xiaozhong Guo, Yun Kou, et al.) Association of lipid profile with decompensation, liver dysfunction, and mortality in patients with liver cirrhosis, Postgraduate Medicine.2021;133:6, 626-638, DOI: 10.1080/00325481.2021.1930560
[ 4 ] Guan R, Lui HF. Treatment of hepatitis B in decompensated liver cirrhosis. Int J Hepatol 2011;2011:918017 .doi:10.4061/2011/918017
[ 5 ] D'Amico G,Pasta L,Morabito A,et al.Competing risks and prognostic stages of cirrhosis: a 25-year inception cohort study of 494 patients. ALIMENTARY PHARMACOLOGY & THERAPEUTICS.2014;39 (10):1180-93. doi:10.1111/apt.12721
[ 6 ] C. Y. Peng, R. N. Chien, and Y. F. Liaw. Hepatitis B virus related decompensated liver cirrhosis: benefits of antiviral therapy. Journal of Hepatology.2012;57 (2):442-50.doi:10.1016/j.jhep.2012.02.033
[ 7 ] Yi, Y; Zhu, D; Li, X; et al. Does Hepatitis B Virus Affect the Coagulation Parameters for HBV-Related Decompensated Cirrhosis?[J].Clin Lab.2021,67(8): doi:10.7754/Clin.Lab.2020.201211
[ 8 ] Xu Changzhi, Yi Yanhua, Xie Zhizhi, et al. Platelets, mean platelet volume, lymphocytes, leukocytes, and ratios of them altered in patients with hepatitis B virus‐related decompensated cirrhosis[J]. Precision Medical Sciences, 2022, 11(2):46-50.
[ 9 ] Chung Tae-Heum,Kim Moon-Chan,Kim Chang-Sup.Association between Hepatitis B Surface Antigen Seropositivity and Metabolic Syndrome.Korean journal of family medicine.2014;35 (2):81-9.doi:10.4082/kjfm.2014.35.2.81
[ 10 ] Quaye Osbourne,Amuzu Benjamin Godfried,Adadey Samuel Mawuli,et al.Effect of Hepatitis B Virus (HBV) Infection on Lipid Profile in Ghanaian Patients.Virology : research and treatment.2019;10:1178122X19827606. doi:10.1177/1178122X19827606
[ 11 ] Nau Angélica Luciana,Soares Júlia Cristina,Shiozawa Maria Beatriz Cacese,et al.Clinical and laboratory characteristics associated with dyslipidemia and liver steatosis in chronic HBV carriers.Revista da Sociedade Brasileira de Medicina Tropical.2014;47 (2):158-64.
[ 12 ] Wang Peng,Wang Yuqi,Liu Hui,et al. Role of triglycerides as a predictor of autoimmune hepatitis with cirrhosis.Lipids in health and disease.2022;21 (1):108.doi:10.1186/s12944-022-01716-9
[ 13 ] Zhang Jiaxuan,Ling Ning,Lei Yu,et al. Multifaceted Interaction Between Hepatitis B Virus Infection and Lipid Metabolism in Hepatocytes: A Potential Target of Antiviral Therapy for Chronic Hepatitis B. Frontiers in microbiology.2021;12:636897.doi:10.3389/fmicb.2021.636897
[ 14 ] Acharya C, Bajaj JS, Microbiota G. Microbiota and Complications of Liver Disease. Gastroenterol Clin North Am. 2017;46(1):155–169. doi:10.1016/j.gtc.2016.09.013
[ 15 ] Yu Yijing,Raka Fitore,Adeli Khosrow.The Role of the Gut Microbiota in Lipid and Lipoprotein Metabolism.Journal of clinical medicine.2019;8 (12).doi:10.3390/jcm8122227
[ 16 ] Hrabovský Vladimír,Mendlová Alice,Zadák Zdeněk,et al.Cholesterol metabolism in acute upper gastrointestinal bleeding, preliminary observations.WIENER KLINISCHE WOCHENSCHRIFT.2012;124 (23-24):815-21.doi:10.1007/s00508-012-0292-0
[ 17 ] Kang Sung-Koo,Chung Tae-Wook,Lee Ji-Young,et al. The hepatitis B virus X protein inhibits secretion of apolipoprotein B by enhancing the expression of N-acetylglucosaminyltransferase III.JOURNAL OF BIOLOGICAL CHEMISTRY.2004;279 (27):28106-12.doi:10.1074/jbc.M403176200
[ 18 ] Larsson Mikael,Allan Christopher M,Jung Rachel S,et al.Apolipoprotein C-III inhibits triglyceride hydrolysis by GPIHBP1-bound LPL.JOURNAL OF LIPID RESEARCH.2017;58 (9):1893-1902.doi:10.1194/jlr.M078220
[ 19 ] Zhu Chengliang, Zhu Hengcheng, Song Hui,et al. Hepatitis B virus inhibits the in vivo and in vitro synthesis and secretion of apolipoprotein C3.Lipids in health and disease.2017;16 (1):213.doi:10.1186/s12944-017-0607-2