RISK FACTORS FOR THE OUTCOME AFTER ALLOGENEIC STEM CELL TRANSPLANTATION: A SINGLE-CENTER EXEPERIENCE

Volume 8, Issue 1, February 2024     |     PP. 1-17      |     PDF (268 K)    |     Pub. Date: March 22, 2024
DOI: 10.54647/pm310251    30 Downloads     32562 Views  

Author(s)

Kameliya Milcheva, Specialized Hospital for Active Treatment of Hematological Diseases
Viktoria Yankova, Specialized Hospital for Active Treatment of Hematological Diseases
Yonka Lazarova, Specialized Hospital for Active Treatment of Hematological Diseases
Krasen Venkov, Specialized Hospital for Active Treatment of Hematological Diseases
Emilia Naseva, Department of Health Economics, Faculty of Public Health "Prof. Tsekomir Vodenicharov, MD, DSc", Medical University of Sofia
Georgi Mihaylov, Specialized Hospital for Active Treatment of Hematological Diseases

Abstract
Allogeneic stem cell transplantation (AlloSCT) is a therapeutic procedure for the treatment of a large number of malignant and non-malignant hematological diseases, unfortunately still associated with significant morbidity and mortality. Disease relapse and non-relapse mortality remain the main causes of treatment failure following AlloSCT. Identification of the risk factors associated with this continue to be a subject of extensive scientific research. The aim of our study is to estimate the risk factors that would have prognostic significance for the outcome of AlloSCT for our patient population. We evaluated 96 patients who received AlloSCT in the transplant unit at Specialized Hospital for Active Treatment of Hematological Diseases (SHATHD), between 2017-2022, with the following diagnoses: acute myeloid leukemia (AML), myelodysplastic syndrome (MDS) and acute lymphoblastic leukemia (ALL. They were prospectively followed up to June 2023. Our results regarding success rates and complications related to the procedure did not differ from data reported in the literature. Along with the common risks for the outcome of AlloSCT, we found as an independent prognostic factors the lymphocyte recovery at D+21 after transplantation and the indicators of cytokine response in the pre engraftmen period.

Keywords
allogeneic stem cell transplantation, risk factors, transplant outcomes, absolute lymphocyte count

Cite this paper
Kameliya Milcheva, Viktoria Yankova, Yonka Lazarova, Krasen Venkov, Emilia Naseva, Georgi Mihaylov, RISK FACTORS FOR THE OUTCOME AFTER ALLOGENEIC STEM CELL TRANSPLANTATION: A SINGLE-CENTER EXEPERIENCE , SCIREA Journal of Medicine. Volume 8, Issue 1, February 2024 | PP. 1-17. 10.54647/pm310251

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